Heart

OPTN/SRTR 2019 Annual Data Report: Heart

Abstract

The new adult heart allocation policy was approved in 2016 and implemented in October 2018. This year’s Annual Data Report provides early insight into the effects of this policy. In 2019, new listings continued to increase, with 4086 new candidates. Also in 2019, 3597 heart transplants were performed, an increase of 157 (4.6%) from 2018; 509 transplants occurred in children and 3088 in adults. Short- and long-term posttransplant mortality rates improved. Overall, Mortality rates for adult recipients were 6.4% at 6 months and 7.9% at 1 year for transplants in 2018, 14.4% at 3 years for transplants in 2016, and 20.1% at 5 years for transplants in 2014. Mortality rates for pediatric recipients were 6.3% at 6 months and 8.2% at 1 year for transplants in 2018, 10.3% at 3 years for transplants in 2016, and 17.8% at 5 years for transplants in 2014.

Introduction

The new adult heart allocation policy was approved in 2016 and implemented in October 2018 to better stratify heart transplant candidates and broaden sharing for higher-urgency statuses to reduce waiting list mortality. While it is too early to discern the impact of the new policy, the more granular data being collected as part of the new system are anticipated to allow improved analyses of outcomes and risk factors, which will contribute to a more dynamic policy. The current Annual Data Report provides an early glimpse into the trends of heart transplant candidates and recipients under the new allocation system.

Adult Heart Transplant

Waiting List Trends

From 2008 to 2019, the number of new listings for heart transplant increased by 42.5%, from 2867 to 4086 (Figure HR 1). The number of candidates awaiting heart transplant increased by 42.6% over 2008 to 2019, from 5304 to 7562 (Figure HR 2). Some notable demographic trends in heart transplant since 2008 include stable proportions of women and men (Figure HR 4), lower proportions of whites (70.4% in 2008 to 60.4% in 2019), higher proportions of blacks, (19.1% to 26.0%) and Hispanics (7.4% to 9.7%) (Figure HR 5), a slight increase in patients with congenital heart disease, and a substantial decrease in patients with coronary artery disease (Figure HR 6). The proportion of candidates diagnosed as having cardiomyopathy continued to increase. Cardiomyopathy is the most common diagnosis among candidates, comprising 59.7% in 2019.

In 2019, 78.4% of candidates had been on the waiting list for less than 1 year, similar to 2009. In 2009, 14.6% of candidates had been on the waiting list for 2 years or longer; this proportion gradually declined to 12.0% in 2019, the lowest in the past decade (Figure HR 7). The proportion of status 1A candidates awaiting transplant continued to increase, while the proportion of status 1B candidates gradually increased, then declined slightly in 2018 (Figure HR 8). Note that new status groups in use as of October 2018 were converted to former status 1A, 1B, and two equivalents for the 2018 data point. New status groups 1-3 were converted to old status 1A, new status 4 to old status 1B, and new status 5 and 6 to old status 2. The proportion of candidates with ventricular assist devices (VADs) at listing increased from 13.5% in 2009 to 37.1% in 2019 (Table HR 2). Sex distribution did not change appreciably: in 2019, women comprised 26.1% of heart transplant candidates (Figure HR 4). As of December 31, 2019, 85.1% of candidates resided in a metropolitan area; 61.5% lived within 50 miles of the transplant center, compared with 57.2% in 2009 (Table HR 1). Numbers of candidates with a previous heart transplant declined from 4.1% in 2009 to 2.8% in 2019 (Table HR 3). At year-end 2019, 253 candidates were listed for heart-kidney transplant, a substantial increase since 2009. The number of heart-lung candidates remained stable over this period, with 74 candidates waiting in 2019 (Table HR 3).

From 2017 to 2019, the number of patients removed from the transplant list increased, but fewer were removed due to improvement or being too ill for transplant (Table HR 5). Compared with 2017, 103 fewer patients died on the waiting list in 2019.

The distribution of candidates by status on December 31, 2019, is shown in Table HR 2. At the end of 2019, 4 patients (0.1%) were listed as status 1, and 48 (1.4%) were status 2. Fewer patients were listed in the highest-urgency categories under the new allocation system, with 50.5% listed as status 4. The number of patients receiving any life support before transplant increased slightly, from 2431 in 2017 to 2519 in 2019, although they represented a smaller proportion of candidates in 2019 than in 2017 (Table HR 7). Of these, 1034 (33.5%) had left-VADs (LVADs), a decrease of 324 over the 2-year period. There was a shift toward intra-aortic balloon pump (IABP) and extracorporeal membrane oxygenation (ECMO), and there was a substantial increase in ventilator support before transplant between 2017 and 2019. In 2019, candidates on IABP comprised nearly one-third of all candidates on life support (Table HR 7).

Since 2015, overall deceased-donor heart transplant rates have increased, to a decade high of 89.5 per 100 waitlist years in 2019 (Figure HR 12). This trend was similar for all age-groups; however, the increase was greatest in candidates 65 and older, with 74.3 per 100 waitlist years in 2015 to 132.2 in 2019 (Figure HR 13). For most groups, transplant rates since 2008 reached a nadir in 2014 and 2015 and have increased since. Transplant rates for Asians exceed that for other ethnic groups (Figure HR 14).

Transplant rates have consistently been highest for candidates with blood type AB (276.6 per 100 waitlist years in 2019), those listed as status 1A under the previous allocation system in 2018 (302.2 per 100), and those now listed as status 1 (1649.0 per 100) (Figure HR 16, Figure HR 18, Figure HR 19). In 2019, blood type O candidates underwent transplant at a rate of 59.7 per 100 waitlist years, less than half the rate of blood type A and B candidates. Despite these differences, transplant rates for all blood types have increased since 2015 (Figure HR 16). From 2008 to 2012, candidates residing in metropolitan areas had higher transplant rates than those in non-metropolitan areas; however, since then, the rates have been more closely aligned. In 2019, the transplant rate was 89.6 per 100 waitlist years for those residing in metropolitan areas and 86.6 per 100 in non-metropolitan areas (Figure HR 21).

The median wait time in 2018-2019 was 5.1 months, the lowest in the past decade. Women typically had a shorter median wait than men and in 2018-2019 underwent transplant at a median of 3.5 months, compared with men (5.9 months) (Figure HR 23). The median wait for candidates with blood type O declined substantially over the past 5 years, from 21.6 months in 2014-2015 to 11.7 months in 2018-2019; however, the median wait for blood type O still far exceeded that of all other blood types (Figure HR 24). Candidates with a body mass index (BMI) of 35 kg/m2 or greater also had longer median waits than other candidates. In 2008-2009, the median wait for candidates with BMI ≥35 kg/m2 was 32.7 months, which declined to 9.7 months in 2018-2019. Candidates with BMI <18.5 kg/m2 had the shortest median wait (1.8 months) (Figure HR 26). The proportion of candidates who underwent transplant within 1 year of listing has varied but has increased since 2014. In 2018, 56.8% of candidates underwent transplant within 1 year of listing (Figure HR 27). When stratified by donation service area (DSA), the proportion of candidates undergoing transplant within 1 year of listing in 2018 was 23.1% to 85.5% (Figure HR 28). Similar variability occurred by state (22.2% to 100%) (Figure HR 29).

Pretransplant mortality declined from 17.4 deaths per 100 waitlist years in 2008 to 8.3 per 100 in 2019 (Figure HR 30). Pretransplant mortality declined for all groups starting in 2009. It was lowest for candidates aged 18-34 years (6.7 per 100 waitlist years) and 35-49 (6.8 per 100) and those listed as status 4 (6.1 per 100) or 6 (6.1 per 100) (Figure HR 31, Figure HR 36). Deaths before transplant declined by more than 50% for all age-groups from 2008 to 2019 (Figure HR 31) and declined substantially over the past decade for black, Hispanic, and Asian candidates. Asians had the largest decline in pretransplant mortality rate, from 28.7 deaths per 100 waitlist years in 2008 to 10.4 deaths per 100 in 2019. Pretransplant mortality was lowest for Hispanics (6.5 deaths per 100) in 2019 (Figure HR 32). Aside from occasional fluctuations, pretransplant mortality rates have been similar between men and women, at 8.15 deaths per 100 waitlist years and 8.36 per 100 in 2019, respectively (Figure HR 33).

Despite a large decline in pretransplant mortality among all statuses under the previous system, patients in the highest-urgency categories still die far more often than those with other statuses. In 2017-2018, candidates listed as status 1A had a pretransplant mortality rate of 29.3 deaths per 100 waitlist years, while status 1B and 2 candidates were similar, at 8.3 deaths per 100 and 7.1 per 100, respectively (Figure HR 35). In 2019, status 1 candidates under the new system had a pretransplant mortality rate of 113.5 deaths per waitlist years, followed by status 2 (42.4 per 100), 5 (33.9 per 100), and 3 (17.2 per 100), respectively (Figure HR 36). It is not possible to compare the pretransplant mortality rates between the new and old systems because of the change in both criteria and practice. From 2006 to 2008, policy changes regarding broader sharing and US Food and Drug Administration approval of LVADs resulted in a change in practice. The large decline in pretransplant mortality likely reflects the combined effect of those changes.

In 2019, 20.6% of candidates died within 6 months of removal from the waiting list (whose removal reasons were any reasons other than transplant or death), more than in the previous 2 years (Figure HR 40). After a peak in 2013, deaths after removal from the list declined despite the increase in 2019.

Donor Trends

The number of deceased-donor hearts continued to increase, with 3635 in 2019, the highest number to date and an increase of 63.6% since 2008 (Figure HR 43). While the number of donors increased in all age-groups since 2008, the greatest increase remained in donors 30-39 years, from 381 in 2008 to 966 in 2019 (Figure HR 44); the highest proportion of donors, 34.8%, was in donors 18-29 years (Figure HR 45). About 70% of donors are men (Figure HR 46). There is little variation by race; most donors are white, which reflects population demographics (Figure HR 47). The proportion of pediatric hearts allocated to adults varied by DSA and in 2015-2019 was 0 to 71.4 (Figure HR 48).

The discard rate (ie, proportion of recovered hearts not transplanted) has fluctuated over the past decade and in 2019 was 0.85% (Figure HR 49). The discard rate for donors aged 55 and older has declined and in 2019 was 2.06, compared with 1.24 in those 40-54 years. Hearts from donors <18 years were least likely to be discarded, at a rate of 0.35 (Figure HR 50). Women’s hearts tended to be discarded more often than men’s, although this has varied (Figure HR 51). Discard rates for Asian donor hearts have fluctuated, but there has been no noticeable race-based trend (Figure HR 52).

In 2019, anoxia slightly exceeded head trauma as the most common cause of death among heart donors (42.8% vs 41.1%) (Figure HR 57).

Trends in Adult Heart Transplant

The number of heart transplants performed in the United States has steadily risen, and in 2019 was 3597 (Figure HR 58). There has been an increase in all age groups; however, recipients 65 and older had the greatest relative increase over the past decade, with 596 transplants in 2019, and 85.1% increase since 2010 (Figure HR 59). The median per-center transplant volume has increased since 2014, from 14 to 23 in 2019 (Figure HR 67). As median volumes increase, the proportion of transplants performed at low-volume centers has declined and the proportion performed at median to high volume centers has increased. In 2019, centers with volumes of 1-9 transplants performed only 2.8% of all procedures, while centers performing 30 or more transplants per year accounted for 63.0% of all heart transplants (Figure HR 68).

The proportion of patients on any type of life support, including inotropic support, declined from 85.6% in 2017 to 81.6% in 2019, although the absolute number increased. There is a growing shift in the use of temporary circulatory support compared with previous years. Notably, LVAD at transplant has declined from 47.8% to 33.5%, while IABP use increased from 8.3% to 29.7%, and ECMO increased from 1.2% to 6.0%. Ventilator use has also increased, from 0.8% to 2.5% (Table HR 7). The typical heart transplant recipient in 2019 was a man (71.6%), white (62.3%), 50-64 years old (47.3%), had private insurance (48.6%), resided in a metropolitan area (85.3%), had cardiomyopathy (62.5%) and blood type A (40.4%), and was status 2 at transplant (47.2%) (Table HR 8, Table HR 9). Between 2009 and 2019, proportions of women and blacks have increased from 24.4% to 28.4% and from 19.3 to 23.1%, respectively (Table HR 8).

Adult Post-transplant Survival and Morbidity

Adult death rates after heart transplant continued to decline; of those who underwent transplant in 2018, 6.4% died by 6 months, and 7.9% died by 1 year. Death rates at all time points have improved over the past decade (Figure HR 69). In patients who underwent transplant from 2012 to 2014, early survival was similar among all age-groups; however, in recipients 65 and older, 1-year survival rates declined compared with younger age groups. The one-year survival rate in recipients aged 35-49 was 90.4%. One-year survival was greatest in recipients aged 18-34, at 90.9%. At 2 years, survival was highest in recipients aged 50-64 (87.6%) and remained so up to year 5, at 80.2%. Recipients aged 18-35 had the lowest 5-year survival rate, at 77.3% (Figure HR 70). Recipients categorized as “other” race had the best 1-year survival rate (93.9%), followed by Asians (92.7%) (Figure HR 71). By year 5, blacks fared substantially worse (75.9%), followed by whites (80.0%). Recipients with congenital heart disease had the lowest 1- and 5-year survival rate (82.2% and 74.2%), while those with valvular heart diseases fared best (84.5%) at 5 years (Figure HR 72). Men and women had comparable survival at all time points (Figure HR 73). Survival in recipients with VADs was 88.4% at 1 year, compared with 90.9% in those without VADs, a trend that appeared within 30 days and continued through 5 years (Figure HR 74). Status 1B recipients fared better than those of other statuses (previous system) (Figure HR 75). The number of survivors after heart transplant continues to increase. On June 30, 2019, 35,713 recipients were alive with a functioning graft, versus 23,315 in 2008 (Figure HR 77). Acute rejection occurred in 25.1% of recipients by 1 year and was most common in adults aged 18-49 (Figure HR 78). Of adult recipients undergoing transplant from 2013 to 2017, PTLD occurred in 0.87% by year 5 and was most common (3.0%) in EBV-negative recipients (Figure HR 80).

Pediatric Heart Transplant

Pediatric Waitlist Trends

In 2019, 694 new pediatric candidates were added to the heart transplant waiting list (Figure HR 81). In 2019, a total of 1087 candidates aged 17 years or younger were awaiting heart transplant (Figure HR 82). The largest pediatric age groups on the waiting list in 2019 were 12-17 years (30.1%) and younger than 1 year (30.0%), followed by 1-5 years (23.3%), and 6-11 years (16.7%) (Figure HR 83). Just over half of pediatric heart transplant candidates were white, 19.6% were black, 19.3% were Hispanic, and 3.3% were Asian (Figure HR 84). The proportion of pediatric heart transplant candidates with congenital defects increased from 46.4% in 2008 to 55.7% in 2019 (Figure HR 85). Considering trends over time, ages and races of waitlisted candidates remained relatively unchanged (Table HR 11). For candidates waiting on December 31, 2019, congenital defect was the leading cause of heart disease at 62.4%, increased from 49.2% in 2009 (Table HR 12). Regarding medical urgency, almost half (46.6%) of pediatric heart transplant candidates were listed as status 1A (Figure HR 88). The proportions listed as status 1B and status 2 increased in 2016 and later, likely reflecting changes to pediatric heart allocation policy implemented in 2016. A smaller proportion of candidates were listed for heart-lung transplant in 2019, 1.6% compared with 4.1 % in 2009 (Table HR 13). Among the 672 candidates removed from the waiting list in 2019, 519 (77.2%) were removed due to undergoing transplant, 55 (8.2%) died, 43 (6.4%) were removed due to improved condition, and 28 (4.2%) were considered too sick to undergo transplant (Table HR 14, Table HR 15).

In 2019, the majority (74.0%) of pediatric heart transplant candidates on the waiting list had been waiting for less than 90 days (Figure HR 87). Just over 70% of pediatric candidates newly listed in 2016 underwent transplant within 3 years, 11.4% died, 14.3% were removed from the list, and 3.8% were still waiting (Figure HR 89). The rate of heart transplant among pediatric waitlist candidates remained relatively stable over the past decade and was 128.5 per 100 waitlist years in 2019 (Figure HR 90). Transplant rates varied by age; 2019 rates were highest for candidates aged 12-17 years at 153.1 transplants per 100 waitlist year, and followed by those aged younger than 1 year at 151.5 transplants per 100 waitlist years. The next are by those aged 6-11 years at 111.2 transplants per 100 waitlist years, and those aged 1-5 years at 94.6 transplants per 100 waitlist years (Figure HR 91). Pretransplant mortality decreased from 33.4 deaths per 100 waitlist years in 2008 to 13.9 in 2019 (Figure HR 94), with notable decreases for candidates aged younger than 1 year (Figure HR 95). Pretransplant mortality rates in 2019 varied by age, and were highest for candidates aged younger than 1 year at 21.0 deaths per 100 waitlist years, followed by 18.9 for ages 1-5 years, 8.4 for ages 12-17 years, and 5.9 for ages 6-11 years (Figure HR 95). By medical urgency status, pretransplant mortality was highest for status 1A (34.4 deaths per 100 waitlist years) and 1B (13.1) candidates, compared with 2.1 for status 2 candidates (Figure HR 98).

Pediatric Trends in Heart Transplant

Pediatric transplant recipients are defined as those aged less than 18 years at the time of transplant. The number of pediatric heart transplants performed each year continued to increase, to 509 in 2019 (Figure HR 100): 181 (35.6%) in recipients aged 11-17 years, 133 (26.1%) in recipients aged < 1 year, 115 (22.6%) in recipients aged 1-5 years, and 80 (15.7%) in recipients aged 6-10 years (Figure HR 101). In 2019, 25 of 137 total heart transplant programs performed pediatric heart transplants exclusively, 77 performed adult heart transplants exclusively, and 35 performed both adult and pediatric heart transplants (Figure HR 102). In 2019, 7.5% of transplants in recipients aged younger than 10 years, 12.0% in recipients aged younger than 15 years, and 15.9% in recipients aged younger than 18 years were performed at programs with volume of five or fewer pediatric transplants in that year (Figure HR 103). Over the past decade, the age, sex, and race/ethnicity of pediatric heart transplant recipients changed little (Table HR 16). Congenital defects remained the most common primary cause of disease, affecting 51.3% of recipients who underwent transplant in 2017-2019 (Table HR 17). The proportion who underwent transplant at status 1A declined slightly, from 82.2% in 2007-2009 to 80.3% in 2017-2019, while the proportion at status 1B increased from 10.5% to 16.2%, and the proportion at status 2 declined from 7.2% to 3.5%. VAD use at the time of transplant increased from 15.7% of transplant recipients in 2007-2009 to 32.4% in 2017-2019 (Table HR 17). The proportion of ABO-incompatible transplants in 2017-2019 increased to 10.5% from 4.0% a decade earlier (Table HR 18).

Over the past decade, induction therapy use increased to 83.7% of pediatric heart transplant recipients in 2019 (Figure HR 104). The initial immunosuppression regimens used most commonly in 2019 were tacrolimus, MMF, and steroids (53.2%), and tacrolimus and MMF (40.1%) (Figure HR 105).

Pediatric Posttransplant Survival and Morbidity

Among 2017-2018 pediatric heart transplant recipients, the rate of acute rejection in the first year was 21.2% overall; the highest rates were 23.7% in recipients aged 11-17 years, and 20.0% in recipients aged 6-10 years and younger than 6 years (Figure HR 107).

Recipient death occurred in 6.3% of patients at 6 months posttransplant and in 8.2% at 1 year among pediatric heart transplants performed in 2018, in 10.3% of patients at 3 years for transplants performed in 2016, in 17.8% of patients at 5 years for transplants performed in 2014, and in 28.7% of patients at 10 years for transplants performed in 2009 (Figure HR 109). Overall, 1-year and 5-year patient survival were 92.0% and 84.1%, respectively, among recipients who underwent transplant in 2012-2014 (Figure HR 110). By age, 5-year patient survival was 81.3% for recipients aged younger than 1 year, 85.1% for ages 1-5 years, 84.8% for ages 6-10 years, and 85.4% for ages 11-17 years (Figure HR 111).

Among pediatric heart transplant recipients 2017-2019, the combination of a CMV-positive donor and CMV-negative recipient occurred in 28.3% of transplants; for EBV, this combination occurred in 28.6% of transplants (Table HR 20). The overall incidence of PTLD was 4.5% at 5 years posttransplant; incidence was 5.7% among EBV-negative recipients and 3.5% among EBV-positive recipients (Figure HR 108).

Figure List

Waiting list

Figure HR 1. New candidates added to the heart transplant waiting list
Figure HR 2. All adult candidates on the heart transplant waiting list
Figure HR 3. Distribution of adults waiting for heart transplant by age
Figure HR 4. Distribution of adults waiting for heart transplant by sex
Figure HR 5. Distribution of adults waiting for heart transplant by race
Figure HR 6. Distribution of adults waiting for heart transplant by diagnosis
Figure HR 7. Distribution of adults waiting for heart transplant by waiting time
Figure HR 8. Distribution of adults waiting for heart transplant by old medical urgency, 2008-2018
Figure HR 9. Distribution of adults waiting for heart transplant by BMI
Figure HR 10. Distribution of adults waiting for heart transplant by blood type
Figure HR 11. Distribution of adults waiting for heart transplant by prior transplant status
Figure HR 12. Overall deceased donor heart transplant rates among adult waitlist candidates
Figure HR 13. Deceased donor heart transplant rates among adult waitlist candidates by age
Figure HR 14. Deceased donor heart transplant rates among adult waitlist candidates by race
Figure HR 15. Deceased donor heart transplant rates among adult waitlist candidates by diagnosis
Figure HR 16. Deceased donor heart transplant rates among adult waitlist candidates by blood type
Figure HR 17. Deceased donor heart transplant rates among adult waitlist candidates by sex
Figure HR 18. Deceased donor heart transplant rates among adult waitlist candidates by former medical urgency groups (Status 1A, 1B, 2), through 2018
Figure HR 19. Deceased donor heart transplant rates among adult waitlist candidates by new medical urgency groups, 2019
Figure HR 20. Deceased donor heart transplant rates among adult waitlist candidates by height
Figure HR 21. Deceased donor heart transplant rates among adult waitlist candidates by metropolitan vs. non-metropolitan residence
Figure HR 22. Three-year outcomes for adults waiting for heart transplant, new listings in 2016
Figure HR 23. Median months to heart transplant for waitlisted adults by sex
Figure HR 24. Median months to heart transplant for waitlisted adults by blood type
Figure HR 25. Median months to heart transplant for waitlisted adults by old medical urgency at listing
Figure HR 26. Median months to heart transplant for waitlisted adults by BMI at listing
Figure HR 27. Percentage of adults who underwent deceased donor heart transplant within a given time period of listing
Figure HR 28. Percentage of adults who underwent deceased donor heart transplant within 1 year of listing, 2018, by DSA
Figure HR 29. Percentage of adults who underwent deceased donor heart transplant within 1 year of listing, 2018, by state
Figure HR 30. Overall pretransplant mortality rates among adults waitlisted for heart transplant
Figure HR 31. Pretransplant mortality rates among adults waitlisted for heart transplant by age
Figure HR 32. Pretransplant mortality rates among adults waitlisted for heart transplant by race
Figure HR 33. Pretransplant mortality rates among adults waitlisted for heart transplant by sex
Figure HR 34. Pretransplant mortality rates among adults waitlisted for heart transplant by diagnosis
Figure HR 35. Pretransplant mortality rates among adults waitlisted for heart transplant by former medical urgency groups (Status 1A, 1B, 2), through 2018
Figure HR 36. Pretransplant mortality rates among adults waitlisted for heart transplant by new medical urgency groups, 2019
Figure HR 37. Pretransplant mortality rates among adults waitlisted for heart transplant by metropolitan vs. non-metropolitan residence
Figure HR 38. Pretransplant mortality rates among adults waitlisted for heart transplant, by active/inactive status
Figure HR 39. Pretransplant mortality rates among adults waitlisted for heart transplant in 2019 by DSA
Figure HR 40. Deaths within six months after removal among adult heart waitlist candidates, overall
Figure HR 41. Deaths within six months after removal among adult heart waitlist candidates, by status at removal
Figure HR 42. Deaths within six months after removal among adult heart waitlist candidates, by age

Deceased donation

Figure HR 43. Overall deceased heart donor count
Figure HR 44. Deceased heart donor count by age
Figure HR 45. Distribution of deceased heart donors by age
Figure HR 46. Distribution of deceased heart donors by sex
Figure HR 47. Distribution of deceased heart donors by race
Figure HR 48. Percent of pediatric donor hearts allocated to adult recipients, by DSA of donor hospital, 2015-2019
Figure HR 49. Overall rates of hearts recovered for transplant and not transplanted
Figure HR 50. Rates of hearts recovered for transplant and not transplanted by donor age
Figure HR 51. Rates of hearts recovered for transplant and not transplanted by donor sex
Figure HR 52. Rates of hearts recovered for transplant and not transplanted by donor race
Figure HR 53. Rates of hearts recovered for transplant and not transplanted by donor hypertension status
Figure HR 54. Rates of hearts recovered for transplant and not transplanted by donor BMI
Figure HR 55. Rates of hearts recovered for transplant and not transplanted by donor cause of death
Figure HR 56. Rates of hearts recovered for transplant and not transplanted, by donor risk of disease transmission
Figure HR 57. Cause of death among deceased heart donors

Transplant

Figure HR 58. Overall heart transplants
Figure HR 59. Total heart transplants by age
Figure HR 60. Total heart transplants by sex
Figure HR 61. Total heart transplants by race
Figure HR 62. Total heart transplants by diagnosis
Figure HR 63. Total heart transplants by former medical urgency groups, 2008-2018
Figure HR 64. Induction agent use in adult heart transplant recipients
Figure HR 65. Immunosuppression regimen use in adult heart transplant recipients
Figure HR 66. Total HLA A, B, and DR mismatches among adult deceased heart transplant recipients, 2015-2019
Figure HR 67. Annual adult heart transplant center volumes by percentile
Figure HR 68. Distribution of adult heart transplants by annual center volume

Outcomes

Figure HR 69. Patient death among adult heart transplant recipients
Figure HR 70. Patient survival among adult heart transplant recipients, 2012-2014, by age
Figure HR 71. Patient survival among adult heart transplant recipients, 2012-2014, by race
Figure HR 72. Patient survival among adult heart transplant recipients, 2012-2014, by diagnosis group
Figure HR 73. Patient survival among adult heart transplant recipients, 2012-2014, by sex
Figure HR 74. Patient survival among adult heart transplant recipients, 2012-2014, by VAD status
Figure HR 75. Patient survival among adult heart transplant recipients, 2012-2014, by medical urgency
Figure HR 76. Patient survival among adult heart transplant recipients, 2012-2014, by metropolitan vs. non-metropolitan recipient residence
Figure HR 77. Recipients alive with a functioning heart graft on June 30 of the year, by age at transplant
Figure HR 78. Incidence of acute rejection by 1 year posttransplant among adult heart transplant recipients by age, 2017-2018
Figure HR 79. Incidence of acute rejection by 1 year posttransplant among adult heart transplant recipients by induction agent, 2017-2018
Figure HR 80. Incidence of PTLD among adult heart transplant recipients by recipient EBV status at transplant, 2013-2017

Pediatric transplant

Figure HR 81. New pediatric candidates added to the heart transplant waiting list
Figure HR 82. All pediatric candidates on the heart transplant waiting list
Figure HR 83. Distribution of pediatric candidates waiting for heart transplant by age
Figure HR 84. Distribution of pediatric candidates waiting for heart transplant by race
Figure HR 85. Distribution of pediatric candidates waiting for heart transplant by diagnosis
Figure HR 86. Distribution of pediatric candidates waiting for heart transplant by sex
Figure HR 87. Distribution of pediatric candidates waiting for heart transplant by waiting time
Figure HR 88. Distribution of pediatric candidates waiting for heart transplant by medical urgency
Figure HR 89. Three-year outcomes for newly listed pediatric candidates waiting for heart transplant, 2016
Figure HR 90. Overall deceased donor heart transplant rates among pediatric waitlist candidates
Figure HR 91. Deceased donor heart transplant rates among pediatric waitlist candidates by age
Figure HR 92. Deceased donor heart transplant rates among pediatric waitlist candidates by race
Figure HR 93. Deceased donor heart transplant rates among pediatric waitlist candidates by metropolitan vs. non-metropolitan residence
Figure HR 94. Overall pretransplant mortality rates among pediatric candidates waitlisted for heart
Figure HR 95. Pretransplant mortality rates among pediatric candidates waitlisted for heart transplant by age
Figure HR 96. Pretransplant mortality rates among pediatric candidates waitlisted for heart transplant by race
Figure HR 97. Pretransplant mortality rates among pediatrics waitlisted for heart transplant by diagnosis
Figure HR 98. Pretransplant mortality rates among pediatrics waitlisted for heart transplant by medical urgency
Figure HR 99. Pretransplant mortality rates among pediatric candidates waitlisted for heart transplant by metropolitan vs. non-metropolitan residence
Figure HR 100. Overall pediatric heart transplants
Figure HR 101. Pediatric heart transplants by recipient age
Figure HR 102. Number of centers performing pediatric and adult heart transplants by center's age mix
Figure HR 103. Pediatric heart recipients at programs that perform 5 or fewer pediatric transplants annually
Figure HR 104. Induction agent use in pediatric heart transplant recipients
Figure HR 105. Immunosuppression regimen use in pediatric heart transplant recipients
Figure HR 106. Total HLA A, B, and DR mismatches among pediatric deceased donor heart transplant recipients, 2015-2019
Figure HR 107. Incidence of acute rejection by 1 year posttransplant among pediatric heart transplant recipients by age, 2017-2018
Figure HR 108. Incidence of PTLD among pediatric heart transplant recipients by recipient EBV status at transplant, 2007-2017
Figure HR 109. Patient death among pediatric heart transplant recipients
Figure HR 110. Overall patient survival among pediatric deceased donor heart transplant recipients, 2012-2014
Figure HR 111. Patient survival among pediatric deceased donor heart transplant recipients, 2012-2014, by recipient age

Table List

Waiting list

Table HR 1. Demographic characteristics of adults on the heart transplant waiting list on December 31, 2009 and December 31, 2019
Table HR 2. Clinical characteristics of adults on the heart transplant waiting list on December 31, 2009 and December 31, 2019
Table HR 3. Listing characteristics of adults on the heart transplant waiting list on December 31, 2009 and December 31, 2019
Table HR 4. Heart transplant waitlist activity among adults
Table HR 5. Removal reason among adult heart transplant candidates
Table HR 6. Percentage of adults who received transplant within 6 months from listing between January 1 and June 30 in 2019

Transplant

Table HR 7. Adult heart recipients on circulatory support before transplant
Table HR 8. Demographic characteristics of adult heart transplant recipients, 2009 and 2019
Table HR 9. Clinical characteristics of adult heart transplant recipients, 2009 and 2019
Table HR 10. Transplant characteristics of adult heart transplant recipients, 2009 and 2019

Pediatric transplant

Table HR 11. Demographic characteristics of pediatric candidates on the heart transplant waiting list on December 31, 2009 and December 31, 2019
Table HR 12. Clinical characteristics of pediatric candidates on the heart transplant waiting list on December 31, 2009 and December 31, 2019
Table HR 13. Listing characteristics of pediatric candidates on the heart transplant waiting list on December 31, 2009 and December 31, 2019
Table HR 14. Heart transplant waitlist activity among pediatric candidates
Table HR 15. Removal reason among pediatric heart transplant candidates
Table HR 16. Demographic characteristics of pediatric heart transplant recipients, 2007-2009 and 2017-2019
Table HR 17. Clinical characteristics of pediatric heart transplant recipients, 2007-2009 and 2017-2019
Table HR 18. Transplant characteristics of pediatric heart transplant recipients, 2007-2009 and 2017-2019
Table HR 19. Pediatric heart recipients on circulatory support before transplant
Table HR 20. Pediatric heart donor-recipient serology matching, 2017-2019

A new candidate is one who first joined the list during the given year, without having been listed in a previous year. Previously listed candidates who underwent transplant and subsequently relisted are considered new. Active and inactive patients are included.

Figure HR 1. New candidates added to the heart transplant waiting list
A new candidate is one who first joined the list during the given year, without having been listed in a previous year. Previously listed candidates who underwent transplant and subsequently relisted are considered new. Active and inactive patients are included.


Adult candidates on the list at any time during the year. Candidates listed at more than one center are counted once per listing.

Figure HR 2. All adult candidates on the heart transplant waiting list
Adult candidates on the list at any time during the year. Candidates listed at more than one center are counted once per listing.


Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Age is determined at the later of listing date or January 1 of the given year. Active and inactive candidates are included.

Figure HR 3. Distribution of adults waiting for heart transplant by age
Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Age is determined at the later of listing date or January 1 of the given year. Active and inactive candidates are included.


Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive patients are included.

Figure HR 4. Distribution of adults waiting for heart transplant by sex
Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive patients are included.


Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive patients are included.

Figure HR 5. Distribution of adults waiting for heart transplant by race
Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive patients are included.


Candidates waiting for transplant at any time in the given year. Active and inactive patients are included.

Figure HR 6. Distribution of adults waiting for heart transplant by diagnosis
Candidates waiting for transplant at any time in the given year. Active and inactive patients are included.


Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing.  Time on the waiting list is determined at the later of listing date or January 1 of the given year. Active and inactive candidates are included.

Figure HR 7. Distribution of adults waiting for heart transplant by waiting time
Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Time on the waiting list is determined at the later of listing date or January 1 of the given year. Active and inactive candidates are included.


Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive candidates are included. The graph only goes through 2018, as the OPTN heart allocation policy changed the status groups in October, 2018. New status codes in use as of October 18, 2018 were converted to their old status equivalents for the 2018 data point.

Figure HR 8. Distribution of adults waiting for heart transplant by old medical urgency, 2008-2018
Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive candidates are included. The graph only goes through 2018, as the OPTN heart allocation policy changed the status groups in October, 2018. New status codes in use as of October 18, 2018 were converted to their old status equivalents for the 2018 data point.


Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive patients are included.

Figure HR 9. Distribution of adults waiting for heart transplant by BMI
Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive patients are included.


Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive patients are included.

Figure HR 10. Distribution of adults waiting for heart transplant by blood type
Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive patients are included.


Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive patients are included.

Figure HR 11. Distribution of adults waiting for heart transplant by prior transplant status
Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive patients are included.


Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately.

Figure HR 12. Overall deceased donor heart transplant rates among adult waitlist candidates
Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately.


Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately. Age is determined at the later of listing date or January 1 of the given year.

Figure HR 13. Deceased donor heart transplant rates among adult waitlist candidates by age
Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately. Age is determined at the later of listing date or January 1 of the given year.


Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately.

Figure HR 14. Deceased donor heart transplant rates among adult waitlist candidates by race
Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately.


Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately.

Figure HR 15. Deceased donor heart transplant rates among adult waitlist candidates by diagnosis
Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately.


Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately.

Figure HR 16. Deceased donor heart transplant rates among adult waitlist candidates by blood type
Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately.


Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately.

Figure HR 17. Deceased donor heart transplant rates among adult waitlist candidates by sex
Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately.


Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately. The graph only goes through 2018, as the OPTN heart allocation policy changed the status groups in October, 2018. Status groups for candidates in late 2018 were converted to old groupings. Medical urgency is determined at the later of listing date and January 1 of the year.

Figure HR 18. Deceased donor heart transplant rates among adult waitlist candidates by former medical urgency groups (Status 1A, 1B, 2), through 2018
Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately. The graph only goes through 2018, as the OPTN heart allocation policy changed the status groups in October, 2018. Status groups for candidates in late 2018 were converted to old groupings. Medical urgency is determined at the later of listing date and January 1 of the year.


Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time. Individual listings are counted separately. Medical urgency is determined at the later of listing date and January 1 of the year.

Figure HR 19. Deceased donor heart transplant rates among adult waitlist candidates by new medical urgency groups, 2019
Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time. Individual listings are counted separately. Medical urgency is determined at the later of listing date and January 1 of the year.


Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately.

Figure HR 20. Deceased donor heart transplant rates among adult waitlist candidates by height
Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately.


Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately. Urban/rural determination is made using the RUCA (Rural-Urban Commuting Area) designation of the candidate

Figure HR 21. Deceased donor heart transplant rates among adult waitlist candidates by metropolitan vs. non-metropolitan residence
Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of wait time in a given year. Individual listings are counted separately. Urban/rural determination is made using the RUCA (Rural-Urban Commuting Area) designation of the candidate's permanent zip code.


Candidates listed at more than one center are counted once per listing. Removed from list includes all reasons except transplant and death. DD, deceased donor.

Figure HR 22. Three-year outcomes for adults waiting for heart transplant, new listings in 2016
Candidates listed at more than one center are counted once per listing. Removed from list includes all reasons except transplant and death. DD, deceased donor.


Observations censored on December 31, 2019; Kaplan-Meier competing risk methods used to estimate time to transplant. Analysis performed per listing. If an estimate is not plotted, 50% of the cohort listed in that year had not undergone transplant by the censoring date. Only the first transplant is counted.

Figure HR 23. Median months to heart transplant for waitlisted adults by sex
Observations censored on December 31, 2019; Kaplan-Meier competing risk methods used to estimate time to transplant. Analysis performed per listing. If an estimate is not plotted, 50% of the cohort listed in that year had not undergone transplant by the censoring date. Only the first transplant is counted.


Observations censored on December 31, 2019; Kaplan-Meier competing risk methods used to estimate time to transplant. Analysis performed per listing. If an estimate is not plotted, 50% of the cohort listed in that year had not undergone transplant by the censoring date. Only the first transplant is counted.

Figure HR 24. Median months to heart transplant for waitlisted adults by blood type
Observations censored on December 31, 2019; Kaplan-Meier competing risk methods used to estimate time to transplant. Analysis performed per listing. If an estimate is not plotted, 50% of the cohort listed in that year had not undergone transplant by the censoring date. Only the first transplant is counted.


Observations censored on December 31, 2018; Kaplan-Meier competing risk methods used to estimate time to transplant. Analysis performed per listing. If an estimate is not plotted, 50% of the cohort listed in that year had not undergone transplant by the censoring date. Only the first transplant is counted. The graph only goes through 2018, as the OPTN heart allocation policy changed the status groups in October, 2018. New status codes in use as of October 18, 2018 were converted to their old status equivalents for the 2018 data point.

Figure HR 25. Median months to heart transplant for waitlisted adults by old medical urgency at listing
Observations censored on December 31, 2018; Kaplan-Meier competing risk methods used to estimate time to transplant. Analysis performed per listing. If an estimate is not plotted, 50% of the cohort listed in that year had not undergone transplant by the censoring date. Only the first transplant is counted. The graph only goes through 2018, as the OPTN heart allocation policy changed the status groups in October, 2018. New status codes in use as of October 18, 2018 were converted to their old status equivalents for the 2018 data point.


Observations censored on December 31, 2019; Kaplan-Meier competing risk methods used to estimate time to transplant. Analysis performed per listing. If an estimate is not plotted, 50% of the cohort listed in that year had not undergone transplant by the censoring date. Only the first transplant is counted.

Figure HR 26. Median months to heart transplant for waitlisted adults by BMI at listing
Observations censored on December 31, 2019; Kaplan-Meier competing risk methods used to estimate time to transplant. Analysis performed per listing. If an estimate is not plotted, 50% of the cohort listed in that year had not undergone transplant by the censoring date. Only the first transplant is counted.


Candidates listed at more than one center are counted once per listing.

Figure HR 27. Percentage of adults who underwent deceased donor heart transplant within a given time period of listing
Candidates listed at more than one center are counted once per listing.


Candidates listed at more than one center are counted once per listing.

Figure HR 28. Percentage of adults who underwent deceased donor heart transplant within 1 year of listing, 2018, by DSA
Candidates listed at more than one center are counted once per listing.


Candidates listed at more than one center are counted once per listing. State is candidate

Figure HR 29. Percentage of adults who underwent deceased donor heart transplant within 1 year of listing, 2018, by state
Candidates listed at more than one center are counted once per listing. State is candidate's home state.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately.

Figure HR 30. Overall pretransplant mortality rates among adults waitlisted for heart transplant
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. Age is determined at the later of listing date or January 1 of the given year.

Figure HR 31. Pretransplant mortality rates among adults waitlisted for heart transplant by age
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. Age is determined at the later of listing date or January 1 of the given year.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately.

Figure HR 32. Pretransplant mortality rates among adults waitlisted for heart transplant by race
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately.

Figure HR 33. Pretransplant mortality rates among adults waitlisted for heart transplant by sex
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately.

Figure HR 34. Pretransplant mortality rates among adults waitlisted for heart transplant by diagnosis
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. Medical urgency is determined at the later of listing date and January 1 of the year.

Figure HR 35. Pretransplant mortality rates among adults waitlisted for heart transplant by former medical urgency groups (Status 1A, 1B, 2), through 2018
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. Medical urgency is determined at the later of listing date and January 1 of the year.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. Medical urgency is determined at the later of listing date and January 1 of the year.

Figure HR 36. Pretransplant mortality rates among adults waitlisted for heart transplant by new medical urgency groups, 2019
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. Medical urgency is determined at the later of listing date and January 1 of the year.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. Urban/rural determination is made using the RUCA (Rural-Urban Commuting Area) designation of the candidate

Figure HR 37. Pretransplant mortality rates among adults waitlisted for heart transplant by metropolitan vs. non-metropolitan residence
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. Urban/rural determination is made using the RUCA (Rural-Urban Commuting Area) designation of the candidate's permanent zip code.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. Status (active/inactive) is assessed on the later of January 1 of the given year and listing date.

Figure HR 38. Pretransplant mortality rates among adults waitlisted for heart transplant, by active/inactive status
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. Status (active/inactive) is assessed on the later of January 1 of the given year and listing date.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately.

Figure HR 39. Pretransplant mortality rates among adults waitlisted for heart transplant in 2019 by DSA
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately.


Denominator includes only candidates removed from the waiting list for reasons other than transplant or death while on the list.

Figure HR 40. Deaths within six months after removal among adult heart waitlist candidates, overall
Denominator includes only candidates removed from the waiting list for reasons other than transplant or death while on the list.


Denominator includes only candidates removed from the waiting list for reasons other than transplant or death while on the list.

Figure HR 41. Deaths within six months after removal among adult heart waitlist candidates, by status at removal
Denominator includes only candidates removed from the waiting list for reasons other than transplant or death while on the list.


Denominator includes only candidates removed from the waiting list for reasons other than transplant or death while on the list. Age is determined at the later of listing date or January 1 of the given year.

Figure HR 42. Deaths within six months after removal among adult heart waitlist candidates, by age
Denominator includes only candidates removed from the waiting list for reasons other than transplant or death while on the list. Age is determined at the later of listing date or January 1 of the given year.


Count of deceased donors whose hearts were recovered for transplant.

Figure HR 43. Overall deceased heart donor count
Count of deceased donors whose hearts were recovered for transplant.


Count of deceased donors whose hearts were recovered for transplant.

Figure HR 44. Deceased heart donor count by age
Count of deceased donors whose hearts were recovered for transplant.


Deceased donors whose hearts were recovered for transplant.

Figure HR 45. Distribution of deceased heart donors by age
Deceased donors whose hearts were recovered for transplant.


Deceased donors whose hearts were recovered for transplant.

Figure HR 46. Distribution of deceased heart donors by sex
Deceased donors whose hearts were recovered for transplant.


Deceased donors whose hearts were recovered for transplant.

Figure HR 47. Distribution of deceased heart donors by race
Deceased donors whose hearts were recovered for transplant.


Numerator: pediatric donor hearts donors allocated to adult recipients. Denominator: total pediatric donor hearts.

Figure HR 48. Percent of pediatric donor hearts allocated to adult recipients, by DSA of donor hospital, 2015-2019
Numerator: pediatric donor hearts donors allocated to adult recipients. Denominator: total pediatric donor hearts.



Percentages of hearts not transplanted out of all hearts recovered for transplant.

Figure HR 49. Overall rates of hearts recovered for transplant and not transplanted
Percentages of hearts not transplanted out of all hearts recovered for transplant.



Percentages of hearts not transplanted out of all hearts recovered for transplant.

Figure HR 50. Rates of hearts recovered for transplant and not transplanted by donor age
Percentages of hearts not transplanted out of all hearts recovered for transplant.



Percentages of hearts not transplanted out of all hearts recovered for transplant.

Figure HR 51. Rates of hearts recovered for transplant and not transplanted by donor sex
Percentages of hearts not transplanted out of all hearts recovered for transplant.



Percentages of hearts not transplanted out of all hearts recovered for transplant.

Figure HR 52. Rates of hearts recovered for transplant and not transplanted by donor race
Percentages of hearts not transplanted out of all hearts recovered for transplant.



Percentages of hearts not transplanted out of all hearts recovered for transplant.

Figure HR 53. Rates of hearts recovered for transplant and not transplanted by donor hypertension status
Percentages of hearts not transplanted out of all hearts recovered for transplant.



Percentages of hearts not transplanted out of all hearts recovered for transplant.

Figure HR 54. Rates of hearts recovered for transplant and not transplanted by donor BMI
Percentages of hearts not transplanted out of all hearts recovered for transplant.



Percentages of hearts not transplanted out of all hearts recovered for transplant.

Figure HR 55. Rates of hearts recovered for transplant and not transplanted by donor cause of death
Percentages of hearts not transplanted out of all hearts recovered for transplant.


Percentages of hearts not transplanted out of all hearts recovered for transplant.  "Increased risk" is defined by criteria from the US Public Health Service Guidelines for increased risk for HIV, hepatitis B and hepatitis C transmission.

Figure HR 56. Rates of hearts recovered for transplant and not transplanted, by donor risk of disease transmission
Percentages of hearts not transplanted out of all hearts recovered for transplant. "Increased risk" is defined by criteria from the US Public Health Service Guidelines for increased risk for HIV, hepatitis B and hepatitis C transmission.


Deceased donors whose hearts were transplanted. CVA, cerebrovascular accident.

Figure HR 57. Cause of death among deceased heart donors
Deceased donors whose hearts were transplanted. CVA, cerebrovascular accident.


All heart transplant recipients, including adult and pediatric, retransplant, and multi-organ recipients.

Figure HR 58. Overall heart transplants
All heart transplant recipients, including adult and pediatric, retransplant, and multi-organ recipients.


All heart transplant recipients, including adult and pediatric, retransplant, and multi-organ recipients.

Figure HR 59. Total heart transplants by age
All heart transplant recipients, including adult and pediatric, retransplant, and multi-organ recipients.


All heart transplant recipients, including adult and pediatric, retransplant, and multi-organ recipients.

Figure HR 60. Total heart transplants by sex
All heart transplant recipients, including adult and pediatric, retransplant, and multi-organ recipients.


All heart transplant recipients, including adult and pediatric, retransplant, and multi-organ recipients.

Figure HR 61. Total heart transplants by race
All heart transplant recipients, including adult and pediatric, retransplant, and multi-organ recipients.


All heart transplant recipients, including adult and pediatric, retransplant, and multi-organ recipients.

Figure HR 62. Total heart transplants by diagnosis
All heart transplant recipients, including adult and pediatric, retransplant, and multi-organ recipients.


All heart transplant recipients, including adult and pediatric, retransplant, and multi-organ recipients. The graph only goes through 2018, as the OPTN heart allocation policy changed the status groups in October, 2018. Urgency groups for recipients who underwent transplant October 18, 2018 or later were converted to former statuses.

Figure HR 63. Total heart transplants by former medical urgency groups, 2008-2018
All heart transplant recipients, including adult and pediatric, retransplant, and multi-organ recipients. The graph only goes through 2018, as the OPTN heart allocation policy changed the status groups in October, 2018. Urgency groups for recipients who underwent transplant October 18, 2018 or later were converted to former statuses.


Immunosuppression at transplant reported to the OPTN.

Figure HR 64. Induction agent use in adult heart transplant recipients
Immunosuppression at transplant reported to the OPTN.


Immunosuppression regimen at transplant reported to the OPTN. Tac, tacrolimus. MMF, all mycophenolate agents.

Figure HR 65. Immunosuppression regimen use in adult heart transplant recipients
Immunosuppression regimen at transplant reported to the OPTN. Tac, tacrolimus. MMF, all mycophenolate agents.


Donor and recipient antigen matching is based on OPTN antigen values and split equivalences policy as of 2018.

Figure HR 66. Total HLA A, B, and DR mismatches among adult deceased heart transplant recipients, 2015-2019
Donor and recipient antigen matching is based on OPTN antigen values and split equivalences policy as of 2018.


Annual volume data are limited to recipients aged 18 years or older.

Figure HR 67. Annual adult heart transplant center volumes by percentile
Annual volume data are limited to recipients aged 18 years or older.


Based on annual volume data among recipients aged 18 or older.

Figure HR 68. Distribution of adult heart transplants by annual center volume
Based on annual volume data among recipients aged 18 or older.


All adult recipients of deceased donor hearts, including multi-organ transplants.

Figure HR 69. Patient death among adult heart transplant recipients
All adult recipients of deceased donor hearts, including multi-organ transplants.


Patient survival estimated using unadjusted Kaplan-Meier methods.

Figure HR 70. Patient survival among adult heart transplant recipients, 2012-2014, by age
Patient survival estimated using unadjusted Kaplan-Meier methods.


Patient survival estimated using unadjusted Kaplan-Meier methods.

Figure HR 71. Patient survival among adult heart transplant recipients, 2012-2014, by race
Patient survival estimated using unadjusted Kaplan-Meier methods.


Patient survival estimated using unadjusted Kaplan-Meier methods.

Figure HR 72. Patient survival among adult heart transplant recipients, 2012-2014, by diagnosis group
Patient survival estimated using unadjusted Kaplan-Meier methods.


Patient survival estimated using unadjusted Kaplan-Meier methods.

Figure HR 73. Patient survival among adult heart transplant recipients, 2012-2014, by sex
Patient survival estimated using unadjusted Kaplan-Meier methods.


Patient survival estimated using unadjusted Kaplan-Meier methods. Ventricular assist device (VAD) status at time of transplant.

Figure HR 74. Patient survival among adult heart transplant recipients, 2012-2014, by VAD status
Patient survival estimated using unadjusted Kaplan-Meier methods. Ventricular assist device (VAD) status at time of transplant.


Patient survival estimated using unadjusted Kaplan-Meier methods.

Figure HR 75. Patient survival among adult heart transplant recipients, 2012-2014, by medical urgency
Patient survival estimated using unadjusted Kaplan-Meier methods.


Patient survival estimated using unadjusted Kaplan-Meier methods.

Figure HR 76. Patient survival among adult heart transplant recipients, 2012-2014, by metropolitan vs. non-metropolitan recipient residence
Patient survival estimated using unadjusted Kaplan-Meier methods.


Recipients are assumed to be alive with function unless a death or graft failure is recorded. A recipient may experience a graft failure and be removed from the cohort, undergo retransplant, and re-enter the cohort.

Figure HR 77. Recipients alive with a functioning heart graft on June 30 of the year, by age at transplant
Recipients are assumed to be alive with function unless a death or graft failure is recorded. A recipient may experience a graft failure and be removed from the cohort, undergo retransplant, and re-enter the cohort.


Only the first reported rejection event is counted. Cumulative incidence is estimated using the Kaplan-Meier method.

Figure HR 78. Incidence of acute rejection by 1 year posttransplant among adult heart transplant recipients by age, 2017-2018
Only the first reported rejection event is counted. Cumulative incidence is estimated using the Kaplan-Meier method.


Only the first reported rejection event is counted. Cumulative incidence is estimated using the Kaplan-Meier method. IL2-RA, interleukin-2 receptor agonist; TCD, T-cell depleting.

Figure HR 79. Incidence of acute rejection by 1 year posttransplant among adult heart transplant recipients by induction agent, 2017-2018
Only the first reported rejection event is counted. Cumulative incidence is estimated using the Kaplan-Meier method. IL2-RA, interleukin-2 receptor agonist; TCD, T-cell depleting.


Cumulative incidence is estimated using the Kaplan-Meier method. PTLD is identified as a reported complication or cause of death on the OPTN Transplant Recipient Follow-up Form or the Posttransplant Malignancy Form as polymorphic PTLD, monomorphic PTLD, or Hodgkin

Figure HR 80. Incidence of PTLD among adult heart transplant recipients by recipient EBV status at transplant, 2013-2017
Cumulative incidence is estimated using the Kaplan-Meier method. PTLD is identified as a reported complication or cause of death on the OPTN Transplant Recipient Follow-up Form or the Posttransplant Malignancy Form as polymorphic PTLD, monomorphic PTLD, or Hodgkin's disease. Only the earliest date of PTLD diagnosis is considered. EBV, Epstein-Barr virus; PTLD, posttransplant lymphoproliferative disorder.


A new candidate is one who first joined the list during the given year, without having been listed in a previous year. Previously listed candidates who underwent transplant and subsequently relisted are considered new. Candidates listed at more than one center are counted once per listing. Active and inactive patients are included.

Figure HR 81. New pediatric candidates added to the heart transplant waiting list
A new candidate is one who first joined the list during the given year, without having been listed in a previous year. Previously listed candidates who underwent transplant and subsequently relisted are considered new. Candidates listed at more than one center are counted once per listing. Active and inactive patients are included.


Pediatric candidates listed at any time during the year. Candidates listed at more than one center are counted once per listing.

Figure HR 82. All pediatric candidates on the heart transplant waiting list
Pediatric candidates listed at any time during the year. Candidates listed at more than one center are counted once per listing.


Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Age is determined at the later of listing date or January 1 of the given year. Active and inactive candidates are included.

Figure HR 83. Distribution of pediatric candidates waiting for heart transplant by age
Candidates waiting for transplant at any time in the given year. Candidates listed at more than one center are counted once per listing. Age is determined at the later of listing date or January 1 of the given year. Active and inactive candidates are included.


Candidates waiting for transplant any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive candidates are included.

Figure HR 84. Distribution of pediatric candidates waiting for heart transplant by race
Candidates waiting for transplant any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive candidates are included.


Candidates waiting for transplant any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive candidates are included. CM, cardiomyopathy.

Figure HR 85. Distribution of pediatric candidates waiting for heart transplant by diagnosis
Candidates waiting for transplant any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive candidates are included. CM, cardiomyopathy.


Candidates waiting for transplant any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive patients are included.

Figure HR 86. Distribution of pediatric candidates waiting for heart transplant by sex
Candidates waiting for transplant any time in the given year. Candidates listed at more than one center are counted once per listing. Active and inactive patients are included.


Candidates waiting for transplant any time in the given year. Candidates listed at more than one center are counted once per listing. Time on the waiting list is determined at the later of listing date or January 1 of the given year. Active and inactive candidates are included.

Figure HR 87. Distribution of pediatric candidates waiting for heart transplant by waiting time
Candidates waiting for transplant any time in the given year. Candidates listed at more than one center are counted once per listing. Time on the waiting list is determined at the later of listing date or January 1 of the given year. Active and inactive candidates are included.


Candidates waiting for transplant any time in the given year. Candidates listed at more than one center are counted once per listing. Medical urgency status is the most severe during the year. Active and inactive patients are included.

Figure HR 88. Distribution of pediatric candidates waiting for heart transplant by medical urgency
Candidates waiting for transplant any time in the given year. Candidates listed at more than one center are counted once per listing. Medical urgency status is the most severe during the year. Active and inactive patients are included.


Pediatric candidates who joined the waitlist in 2016. Pediatric candidates listed at more than one center are counted once per listing. Removed from list includes all reasons except transplant and death. DD, deceased donor.

Figure HR 89. Three-year outcomes for newly listed pediatric candidates waiting for heart transplant, 2016
Pediatric candidates who joined the waitlist in 2016. Pediatric candidates listed at more than one center are counted once per listing. Removed from list includes all reasons except transplant and death. DD, deceased donor.


Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of waiting in a given year. Individual listings are counted separately. Age is determined at the later of listing date or January 1 of the given year.

Figure HR 90. Overall deceased donor heart transplant rates among pediatric waitlist candidates
Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of waiting in a given year. Individual listings are counted separately. Age is determined at the later of listing date or January 1 of the given year.


Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of waiting in a given year. Individual listings are counted separately. Age is determined at the later of listing date or January 1 of the given year.

Figure HR 91. Deceased donor heart transplant rates among pediatric waitlist candidates by age
Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of waiting in a given year. Individual listings are counted separately. Age is determined at the later of listing date or January 1 of the given year.


Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of waiting in a given year. Individual listings are counted separately. Age is determined at the later of listing date or January 1 of the given year.

Figure HR 92. Deceased donor heart transplant rates among pediatric waitlist candidates by race
Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of waiting in a given year. Individual listings are counted separately. Age is determined at the later of listing date or January 1 of the given year.


Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of waiting in a given year. Individual listings are counted separately.

Figure HR 93. Deceased donor heart transplant rates among pediatric waitlist candidates by metropolitan vs. non-metropolitan residence
Transplant rates are computed as the number of deceased donor transplants per 100 patient-years of waiting in a given year. Individual listings are counted separately.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. Individual listings are counted separately.

Figure HR 94. Overall pretransplant mortality rates among pediatric candidates waitlisted for heart
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. Individual listings are counted separately.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. Age is determined at the later of listing date or January 1 of the given year.

Figure HR 95. Pretransplant mortality rates among pediatric candidates waitlisted for heart transplant by age
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. Age is determined at the later of listing date or January 1 of the given year.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately.

Figure HR 96. Pretransplant mortality rates among pediatric candidates waitlisted for heart transplant by race
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. CM, cardiomyopathy.

Figure HR 97. Pretransplant mortality rates among pediatrics waitlisted for heart transplant by diagnosis
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. CM, cardiomyopathy.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately.

Figure HR 98. Pretransplant mortality rates among pediatrics waitlisted for heart transplant by medical urgency
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately.


Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately.  Urban/rural determination is made using the RUCA (Rural-Urban Commuting Area) designation of the candidate

Figure HR 99. Pretransplant mortality rates among pediatric candidates waitlisted for heart transplant by metropolitan vs. non-metropolitan residence
Mortality rates are computed as the number of deaths per 100 patient-years of waiting in the given year. Waiting time is censored at transplant, death, transfer to another program, removal because of improved condition, or end of cohort. Individual listings are counted separately. Urban/rural determination is made using the RUCA (Rural-Urban Commuting Area) designation of the candidate's permanent zip code.


All pediatric heart transplant recipients, including retransplant, and multi-organ recipients.

Figure HR 100. Overall pediatric heart transplants
All pediatric heart transplant recipients, including retransplant, and multi-organ recipients.


All pediatric heart transplant recipients, including retransplant, and multi-organ recipients.

Figure HR 101. Pediatric heart transplants by recipient age
All pediatric heart transplant recipients, including retransplant, and multi-organ recipients.


Adult centers transplanted only recipients aged 18 years or older. Functionally adult centers transplanted 80% adults or more, and the remainder were children aged 15-17 years. Mixed included adults and children of any age groups. Pediatric center transplanted recipients aged 0-17 years, and a small number of adults up to age 21 years.

Figure HR 102. Number of centers performing pediatric and adult heart transplants by center's age mix
Adult centers transplanted only recipients aged 18 years or older. Functionally adult centers transplanted 80% adults or more, and the remainder were children aged 15-17 years. Mixed included adults and children of any age groups. Pediatric center transplanted recipients aged 0-17 years, and a small number of adults up to age 21 years.


Age groups are cumulative.

Figure HR 103. Pediatric heart recipients at programs that perform 5 or fewer pediatric transplants annually
Age groups are cumulative.


Immunosuppression at transplant reported to the OPTN.

Figure HR 104. Induction agent use in pediatric heart transplant recipients
Immunosuppression at transplant reported to the OPTN.


Immunosuppression regimen at transplant reported to the OPTN. Tac, tacrolimus. MMF, all mycophenolate agents.

Figure HR 105. Immunosuppression regimen use in pediatric heart transplant recipients
Immunosuppression regimen at transplant reported to the OPTN. Tac, tacrolimus. MMF, all mycophenolate agents.


Donor and recipient antigen matching is based on OPTN antigen values and split equivalences policy as of 2018.

Figure HR 106. Total HLA A, B, and DR mismatches among pediatric deceased donor heart transplant recipients, 2015-2019
Donor and recipient antigen matching is based on OPTN antigen values and split equivalences policy as of 2018.


Only the first reported rejection event is counted. Cumulative incidence is estimated using the Kaplan-Meier method.

Figure HR 107. Incidence of acute rejection by 1 year posttransplant among pediatric heart transplant recipients by age, 2017-2018
Only the first reported rejection event is counted. Cumulative incidence is estimated using the Kaplan-Meier method.


Cumulative incidence is estimated using the Kaplan-Meier method. PTLD is identified as a reported complication or cause of death on the OPTN Transplant Recipient Follow-up Form or on the Posttransplant Malignancy Form as polymorphic PTLD, monomorphic PTLD, or Hodgkin

Figure HR 108. Incidence of PTLD among pediatric heart transplant recipients by recipient EBV status at transplant, 2007-2017
Cumulative incidence is estimated using the Kaplan-Meier method. PTLD is identified as a reported complication or cause of death on the OPTN Transplant Recipient Follow-up Form or on the Posttransplant Malignancy Form as polymorphic PTLD, monomorphic PTLD, or Hodgkin's disease. Only the earliest date of PTLD diagnosis is considered. EBV, Epstein-Barr virus.


All pediatric recipients of deceased donor hearts, including multi-organ transplants.  Estimates are unadjusted, computed using Kaplan-Meier competing risk methods. Recipients are followed to the earliest of kidney graft failure; kidney retransplant; return to dialysis; death; or 6 months, 1, 3, 5, or 10 years posttransplant.

Figure HR 109. Patient death among pediatric heart transplant recipients
All pediatric recipients of deceased donor hearts, including multi-organ transplants. Estimates are unadjusted, computed using Kaplan-Meier competing risk methods. Recipients are followed to the earliest of kidney graft failure; kidney retransplant; return to dialysis; death; or 6 months, 1, 3, 5, or 10 years posttransplant.


Recipient survival estimated using unadjusted Kaplan-Meier methods.

Figure HR 110. Overall patient survival among pediatric deceased donor heart transplant recipients, 2012-2014
Recipient survival estimated using unadjusted Kaplan-Meier methods.


Recipient survival estimated using unadjusted Kaplan-Meier methods.

Figure HR 111. Patient survival among pediatric deceased donor heart transplant recipients, 2012-2014, by recipient age
Recipient survival estimated using unadjusted Kaplan-Meier methods.


Table HR 1. Demographic characteristics of adults on the heart transplant waiting list on December 31, 2009 and December 31, 2019
Candidates waiting for transplant on December 31 of the given year, regardless of first listing date. Distance is computed from candidate's home zip code to the transplant center.
Characteristic 2009, N 2009, Percent 2019, N 2019, Percent
Age: 18-34 years 299 11.0% 374 11.0%
Age: 35-49 years 610 22.4% 815 24.1%
Age: 50-64 years 1393 51.0% 1642 48.5%
Age: ≥ 65 years 427 15.6% 554 16.4%
Sex: Female 706 25.9% 783 23.1%
Sex: Male 2023 74.1% 2602 76.9%
Race/ethnicity: White 1945 71.3% 1996 59.0%
Race/ethnicity: Black 529 19.4% 965 28.5%
Race/ethnicity: Hispanic 187 6.9% 325 9.6%
Race/ethnicity: Asian 47 1.7% 74 2.2%
Race/ethnicity: Other/unknown 21 0.8% 25 0.7%
Geography: Metropolitan 2240 82.1% 2879 85.1%
Geography: Non-metro 489 17.9% 506 14.9%
Distance: < 50 miles 1561 57.2% 2081 61.5%
Distance: 50-<100 miles 488 17.9% 537 15.9%
Distance: 100-<150 miles 278 10.2% 335 9.9%
Distance: 150-<250 miles 193 7.1% 210 6.2%
Distance: ≥ 250 miles 188 6.9% 208 6.1%
Distance: Unknown 21 0.8% 14 0.4%
All candidates 2729 100.0% 3385 100.0%



Table HR 2. Clinical characteristics of adults on the heart transplant waiting list on December 31, 2009 and December 31, 2019
Candidates waiting for transplant on December 31 of the given year, regardless of first listing date. VAD, ventricular assist device.
Characteristic 2009, N 2009, Percent 2019, N 2019, Percent
Diagnosis: Coronary artery disease 1099 40.3% 978 28.9%
Diagnosis: Cardiomyopathy 1264 46.3% 2015 59.5%
Diagnosis: Congenital disease 154 5.6% 187 5.5%
Diagnosis: Valvular disease 57 2.1% 37 1.1%
Diagnosis: Other/unknown 155 5.7% 168 5.0%
Blood type: A 882 32.3% 966 28.5%
Blood type: B 259 9.5% 369 10.9%
Blood type: AB 43 1.6% 61 1.8%
Blood type: O 1545 56.6% 1989 58.8%
Medical urgency: Former Status 1A 155 5.7% 0 0.0%
Medical urgency: Former Status 1B 734 26.9% 0 0.0%
Medical urgency: Former Status 2 981 35.9% 1 0.0%
Medical urgency: New Status 1 0 0.0% 4 0.1%
Medical urgency: New Status 2 0 0.0% 48 1.4%
Medical urgency: New Status 3 0 0.0% 217 6.4%
Medical urgency: New Status 4 0 0.0% 1710 50.5%
Medical urgency: New Status 5 0 0.0% 108 3.2%
Medical urgency: New Status 6 0 0.0% 502 14.8%
Medical urgency: Inactive 859 31.5% 795 23.5%
VAD at listing 368 13.5% 1257 37.1%
All candidates 2729 100.0% 3385 100.0%



Table HR 3. Listing characteristics of adults on the heart transplant waiting list on December 31, 2009 and December 31, 2019
Candidates waiting for transplant on December 31 of the given year, regardless of first listing date.
Characteristic 2009, N 2009, Percent 2019, N 2019, Percent
Transplant history: First 2616 95.9% 3289 97.2%
Transplant history: Retransplant 113 4.1% 96 2.8%
Wait time: < 1 year 1467 53.8% 1616 47.7%
Wait time: 1-< 2 years 508 18.6% 863 25.5%
Wait time: 2-< 3 years 223 8.2% 376 11.1%
Wait time: 3-< 4 years 133 4.9% 212 6.3%
Wait time: 4-< 5 years 61 2.2% 119 3.5%
Wait time: ≥ 5 years 337 12.3% 199 5.9%
Tx type: Heart only 2545 93.3% 3022 89.3%
Tx type: Heart-kidney 94 3.4% 253 7.5%
Tx type: Heart-lung 72 2.6% 74 2.2%
Tx type: Other 18 0.7% 36 1.1%
All candidates 2729 100.0% 3385 100.0%



Table HR 4. Heart transplant waitlist activity among adults
Candidates listed at more than one center are counted once per listing. Candidates who are listed, undergo transplant, and are relisted are counted more than once. Candidates are not considered to be on the list on the day they are removed; counts on January 1 may differ from counts on December 31 of the prior year. Candidates listed for multi-organ transplants are included.
Waiting list state 2017 2018 2019
Patients at start of year 3703 3591 3467
Patients added during year 3947 4072 4087
Patients removed during year 4050 4187 4167
Patients at end of year 3600 3476 3387



Table HR 5. Removal reason among adult heart transplant candidates
Removal reason as reported to the OPTN. Candidates with death dates that precede removal dates are assumed to have died waiting.
Removal reason 2017 2018 2019
Deceased donor transplant 2820 2948 3066
Patient died 302 273 199
Patient refused transplant 27 27 25
Improved, transplant not needed 185 183 163
Too sick for transplant 294 280 261
Other 420 476 453



Table HR 6. Percentage of adults who received transplant within 6 months from listing between January 1 and June 30 in 2019
Candidates are newly listed within the interval.
Status at listing Percent
1 80.0%
2 88.6%
3 76.0%
4 42.2%
5 35.7%
6 39.2%



Table HR 7. Adult heart recipients on circulatory support before transplant
Patients may have more than one type of circulatory support.
Support 2017, N 2017, Percent 2019, N 2019, Percent
Any life support 2431 85.6% 2519 81.6%
Left ventricular assist device 1358 47.8% 1034 33.5%
Intravenous inotropes 1019 35.9% 1168 37.8%
Intra-aortic balloon pump 235 8.3% 917 29.7%
Right ventricular assist device 48 1.7% 69 2.2%
Extra corporeal membrane oxygenation 34 1.2% 184 6.0%
Total artificial heart 23 0.8% 26 0.8%
Ventilator 22 0.8% 76 2.5%
Inhaled NO 5 0.2% 7 0.2%
Prostaglandins 1 0.0% 7 0.2%



Table HR 8. Demographic characteristics of adult heart transplant recipients, 2009 and 2019
Heart transplant recipients, including retransplants. Distance is computed from recipient's home zip code to the transplant center.
Characteristic 2009, N 2009, Percent 2019, N 2019, Percent
Age: 18-34 years 216 11.5% 377 12.2%
Age: 35-49 years 407 21.7% 654 21.2%
Age: 50-64 years 969 51.6% 1461 47.3%
Age: ≥ 65 years 287 15.3% 596 19.3%
Sex: Female 459 24.4% 877 28.4%
Sex: Male 1420 75.6% 2211 71.6%
Race/ethnicity: White 1307 69.6% 1924 62.3%
Race/ethnicity: Black 362 19.3% 713 23.1%
Race/ethnicity: Hispanic 141 7.5% 305 9.9%
Race/ethnicity: Asian 58 3.1% 123 4.0%
Race/ethnicity: Other/unknown 11 0.6% 23 0.7%
Insurance: Private 1031 54.9% 1500 48.6%
Insurance: Medicare 573 30.5% 1007 32.6%
Insurance: Medicaid 210 11.2% 419 13.6%
Insurance: Other government 49 2.6% 124 4.0%
Insurance: Unknown 16 0.9% 38 1.2%
Geography: Metropolitan 1554 82.7% 2635 85.3%
Geography: Non-metro 325 17.3% 453 14.7%
Distance: < 50 miles 1122 59.7% 1880 60.9%
Distance: 50-<100 miles 319 17.0% 483 15.6%
Distance: 100-<150 miles 197 10.5% 319 10.3%
Distance: 150-<250 miles 124 6.6% 224 7.3%
Distance: ≥ 250 miles 102 5.4% 152 4.9%
Distance: Unknown 15 0.8% 30 1.0%
All recipients 1879 100.0% 3088 100.0%



Table HR 9. Clinical characteristics of adult heart transplant recipients, 2009 and 2019
Heart transplant recipients, including retransplants. Ventricular assist device (VAD) information is from the OPTN Transplant Recipient Registration Form and includes left VAD, right VAD, total artificial heart, and left + right VAD. Collection of calculated PRA (CPRA) began March 31, 2015. Prior to that, PRA class I and II values were used.
Characteristic 2009, N 2009, Percent 2019, N 2019, Percent
Diagnosis: Coronary artery disease 733 39.0% 859 27.8%
Diagnosis: Cardiomyopathy 1002 53.3% 1930 62.5%
Diagnosis: Congenital disease 60 3.2% 151 4.9%
Diagnosis: Valvular disease 41 2.2% 38 1.2%
Diagnosis: Other/unknown 43 2.3% 110 3.6%
Blood type: A 785 41.8% 1247 40.4%
Blood type: B 278 14.8% 481 15.6%
Blood type: AB 92 4.9% 165 5.3%
Blood type: O 724 38.5% 1195 38.7%
On VAD 721 38.4% 1110 35.9%
CPRA: < 1% 1104 58.8% 1408 45.6%
CPRA: 1-< 20% 384 20.4% 338 10.9%
CPRA: 20-< 80% 267 14.2% 492 15.9%
CPRA: 80-< 98% 59 3.1% 86 2.8%
CPRA: 98-100% 24 1.3% 48 1.6%
CPRA: Unknown 41 2.2% 716 23.2%
Medical urgency: Former Status 1A 974 51.8% 0 0.0%
Medical urgency: Former Status 1B 750 39.9% 0 0.0%
Medical urgency: Former Status 2 155 8.2% 0 0.0%
Medical urgency: New Status 1 0 0.0% 289 9.4%
Medical urgency: New Status 2 0 0.0% 1456 47.2%
Medical urgency: New Status 3 0 0.0% 650 21.0%
Medical urgency: New Status 4 0 0.0% 546 17.7%
Medical urgency: New Status 5 0 0.0% 29 0.9%
Medical urgency: New Status 6 0 0.0% 118 3.8%
All recipients 1879 100.0% 3088 100.0%



Table HR 10. Transplant characteristics of adult heart transplant recipients, 2009 and 2019
Heart transplant recipients, including retransplants.
Characteristic 2009, N 2009, Percent 2019, N 2019, Percent
Wait time: < 31 days 455 24.2% 1420 46.0%
Wait time: 31-60 days 262 13.9% 334 10.8%
Wait time: 61-90 days 193 10.3% 204 6.6%
Wait time: 3-< 6 months 379 20.2% 335 10.8%
Wait time: 6-< 12 months 322 17.1% 338 10.9%
Wait time: 1-< 2 years 177 9.4% 262 8.5%
Wait time: ≥ 2 years 91 4.8% 195 6.3%
Transplant history: First 1815 96.6% 2984 96.6%
Transplant history: Retransplant 64 3.4% 104 3.4%
Tx type: Heart only 1782 94.8% 2782 90.1%
Tx type: Heart-lung 24 1.3% 42 1.4%
Tx type: Heart-kidney 59 3.1% 213 6.9%
Tx type: Heart-liver 11 0.6% 44 1.4%
Tx type: Other 3 0.2% 7 0.2%
All recipients 1879 100.0% 3088 100.0%



Table HR 11. Demographic characteristics of pediatric candidates on the heart transplant waiting list on December 31, 2009 and December 31, 2019
Candidates aged younger than 18 years waiting for transplant on December 31 of given year, regardless of first listing date. Age calculated at snapshot. Candidates listed as children who turned 18 before the cohort date are excluded. Distance is computed from candidate's home zip code to the transplant center.
Characteristic 2009, N 2009, Percent 2019, N 2019, Percent
Age: < 1 year 43 16.2% 65 17.3%
Age: 1-5 years 82 30.8% 120 32.0%
Age: 6-10 years 57 21.4% 73 19.5%
Age: 11-17 years 84 31.6% 117 31.2%
Sex: Female 102 38.3% 167 44.5%
Sex: Male 164 61.7% 208 55.5%
Race/ethnicity: White 149 56.0% 208 55.5%
Race/ethnicity: Black 57 21.4% 74 19.7%
Race/ethnicity: Hispanic 53 19.9% 70 18.7%
Race/ethnicity: Asian 6 2.3% 11 2.9%
Race/ethnicity: Other/unknown 1 0.4% 12 3.2%
Geography: Metropolitan 232 87.2% 306 81.6%
Geography: Non-metro 34 12.8% 69 18.4%
Distance: < 50 miles 135 50.8% 189 50.4%
Distance: 50-<100 miles 45 16.9% 74 19.7%
Distance: 100-<150 miles 28 10.5% 44 11.7%
Distance: 150-<250 miles 25 9.4% 36 9.6%
Distance: ≥ 250 miles 29 10.9% 27 7.2%
Distance: Unknown 4 1.5% 5 1.3%
All candidates 266 100.0% 375 100.0%



Table HR 12. Clinical characteristics of pediatric candidates on the heart transplant waiting list on December 31, 2009 and December 31, 2019
Candidates aged younger than 18 years waiting for transplant on December 31 of the given year, regardless of first listing date. Candidates listed as children who turned 18 before the cohort date are excluded. CM, cardiomyopathy; VAD, ventricular assist device.
Characteristic 2009, N 2009, Percent 2019, N 2019, Percent
Diagnosis: Congenital defect 131 49.2% 234 62.4%
Diagnosis: Idiopathic dilated CM 58 21.8% 53 14.1%
Diagnosis: Familial dilated CM 5 1.9% 6 1.6%
Diagnosis: Idiopathic restrictive CM 14 5.3% 10 2.7%
Diagnosis: Myocarditis 15 5.6% 5 1.3%
Diagnosis: Other/unknown 43 16.2% 67 17.9%
Blood type: A 74 27.8% 118 31.5%
Blood type: B 34 12.8% 46 12.3%
Blood type: AB 10 3.8% 8 2.1%
Blood type: O 148 55.6% 203 54.1%
Medical urgency: Former Status 1A 75 28.2% 88 23.5%
Medical urgency: Former Status 1B 19 7.1% 72 19.2%
Medical urgency: Former Status 2 46 17.3% 113 30.1%
Medical urgency: Inactive 126 47.4% 102 27.2%
VAD at listing 9 3.4% 20 5.3%
All candidates 266 100.0% 375 100.0%



Table HR 13. Listing characteristics of pediatric candidates on the heart transplant waiting list on December 31, 2009 and December 31, 2019
Candidates aged younger than 18 years waiting for transplant on December 31 of the given year, regardless of first listing date. Candidates listed as children who turned 18 before the cohort date are excluded.
Characteristic 2009, N 2009, Percent 2019, N 2019, Percent
Transplant history: First 249 93.6% 357 95.2%
Transplant history: Retransplant 17 6.4% 18 4.8%
Wait time: < 1 year 160 60.2% 231 61.6%
Wait time: 1-< 2 years 30 11.3% 67 17.9%
Wait time: 2-< 3 years 21 7.9% 36 9.6%
Wait time: 3-< 4 years 8 3.0% 19 5.1%
Wait time: 4-< 5 years 10 3.8% 8 2.1%
Wait time: ≥ 5 years 37 13.9% 14 3.7%
Tx type: Heart only 252 94.7% 364 97.1%
Tx type: Heart-kidney 2 0.8% 2 0.5%
Tx type: Heart-lung 11 4.1% 6 1.6%
Tx type: Other 1 0.4% 3 0.8%
All candidates 266 100.0% 375 100.0%



Table HR 14. Heart transplant waitlist activity among pediatric candidates
Candidates who are listed, undergo transplant, and are relisted are counted more than once. Candidates are not considered to be on the list on the day they are removed; counts on January 1 may differ from counts on December 31 of the prior year. Candidates listed for multi-organ transplants are included.
Waiting list state 2017 2018 2019
Patients at start of year 364 382 392
Patients added during year 636 707 694
Patients removed during year 618 696 672
Patients at end of year 382 393 414



Table HR 15. Removal reason among pediatric heart transplant candidates
Removal reason as reported to the OPTN. Candidates with death dates that precede removal dates are assumed to have died waiting.
Removal reason 2017 2018 2019
Deceased donor transplant 443 484 519
Patient died 68 80 55
Patient refused transplant 0 2 3
Improved, transplant not needed 55 62 43
Too sick for transplant 28 31 28
Other 24 37 24



Table HR 16. Demographic characteristics of pediatric heart transplant recipients, 2007-2009 and 2017-2019
Pediatric heart transplant recipients, including retransplants. Distance is computed from recipient's home zip code to the transplant center.
Characteristic 2007-09, N 2007-09, Percent 2017-19, N 2017-19, Percent
Age: < 1 year 304 28.6% 364 25.7%
Age: 1-5 years 263 24.7% 336 23.8%
Age: 6-10 years 153 14.4% 195 13.8%
Age: 11-17 years 344 32.3% 519 36.7%
Sex: Female 484 45.5% 625 44.2%
Sex: Male 580 54.5% 789 55.8%
Race/ethnicity: White 567 53.3% 738 52.2%
Race/ethnicity: Black 212 19.9% 280 19.8%
Race/ethnicity: Hispanic 197 18.5% 284 20.1%
Race/ethnicity: Asian 65 6.1% 69 4.9%
Race/ethnicity: Other/unknown 23 2.2% 43 3.0%
Insurance: Private 513 48.2% 548 38.8%
Insurance: Medicaid 426 40.0% 733 51.8%
Insurance: Other government 86 8.1% 96 6.8%
Insurance: Unknown 39 3.7% 37 2.6%
Geography: Metropolitan 897 84.3% 1142 80.8%
Geography: Non-metro 167 15.7% 272 19.2%
Distance: < 50 miles 547 51.4% 756 53.5%
Distance: 50-<100 miles 148 13.9% 248 17.5%
Distance: 100-<150 miles 119 11.2% 148 10.5%
Distance: 150-<250 miles 98 9.2% 121 8.6%
Distance: ≥ 250 miles 130 12.2% 112 7.9%
Distance: Unknown 22 2.1% 29 2.1%
All recipients 1064 100.0% 1414 100.0%



Table HR 17. Clinical characteristics of pediatric heart transplant recipients, 2007-2009 and 2017-2019
Pediatric heart transplant recipients, including retransplants. Collection of calculated PRA (CPRA) began March 31, 2015. Prior to that, measured PRA values were used. CM, cardiomyopathy; VAD, ventricular assist device.
Characteristic 2007-09, N 2007-09, Percent 2017-19, N 2017-19, Percent
Diagnosis: Congenital defect 455 42.8% 726 51.3%
Diagnosis: Idiopathic dilated CM 318 29.9% 306 21.6%
Diagnosis: Familial dilated CM 36 3.4% 79 5.6%
Diagnosis: Idiopathic restrictive CM 70 6.6% 58 4.1%
Diagnosis: Myocarditis 50 4.7% 38 2.7%
Diagnosis: Other/unknown 135 12.7% 207 14.6%
Blood type: A 385 36.2% 487 34.4%
Blood type: B 146 13.7% 204 14.4%
Blood type: AB 42 3.9% 66 4.7%
Blood type: O 491 46.1% 657 46.5%
Medical urgency: Former Status 1A 875 82.2% 1136 80.3%
Medical urgency: Former Status 1B 112 10.5% 229 16.2%
Medical urgency: Former Status 2 77 7.2% 49 3.5%
On VAD 167 15.7% 458 32.4%
CPRA: < 1% 599 56.3% 552 39.0%
CPRA: 1-< 20% 180 16.9% 188 13.3%
CPRA: 20-< 80% 138 13.0% 259 18.3%
CPRA: 80-< 98% 42 3.9% 74 5.2%
CPRA: 98-100% 28 2.6% 57 4.0%
CPRA: Unknown 77 7.2% 284 20.1%
All recipients 1064 100.0% 1414 100.0%



Table HR 18. Transplant characteristics of pediatric heart transplant recipients, 2007-2009 and 2017-2019
Pediatric transplant recipients, including retransplants.
Characteristic 2007-09, N 2007-09, Percent 2017-19, N 2017-19, Percent
Wait time: < 31 days 438 41.2% 403 28.5%
Wait time: 31-60 days 205 19.3% 235 16.6%
Wait time: 61-90 days 127 11.9% 203 14.4%
Wait time: 3-< 6 months 152 14.3% 291 20.6%
Wait time: 6-< 12 months 98 9.2% 167 11.8%
Wait time: 1-< 2 years 25 2.3% 83 5.9%
Wait time: ≥ 2 years 19 1.8% 32 2.3%
ABO: Compatible/identical 1021 96.0% 1266 89.5%
ABO: Incompatible 43 4.0% 148 10.5%
Transplant history: First 990 93.0% 1360 96.2%
Transplant history: Retransplant 74 7.0% 54 3.8%
Tx type: Heart only 1043 98.0% 1393 98.5%
Tx type: Other 1 0.1% 0 0.0%
Tx type: Heart-lung 12 1.1% 8 0.6%
Tx type: Heart-kidney 7 0.7% 10 0.7%
Tx type: Heart-liver 1 0.1% 3 0.2%
All recipients 1064 100.0% 1414 100.0%



Table HR 19. Pediatric heart recipients on circulatory support before transplant
Patients may have more than one type of circulatory support.
Support 2014, N 2014, Percent 2019, N 2019, Percent
Any life support 293 71.5% 378 74.3%
Intravenous inotropes 198 48.3% 240 47.2%
Left ventricular assist device 103 25.1% 164 32.2%
Ventilator 59 14.4% 53 10.4%
Right ventricular assist device 27 6.6% 34 6.7%
Prostaglandins 15 3.7% 8 1.6%
Extra corporeal membrane oxygenation 13 3.2% 10 2.0%
Inhaled NO 8 2.0% 4 0.8%
Intra-aortic balloon pump 2 0.5% 4 0.8%
Total artificial heart 1 0.2% 1 0.2%



Table HR 20. Pediatric heart donor-recipient serology matching, 2017-2019
Donor serology is reported on the OPTN Donor Registration Form and recipient serology on the OPTN Transplant Recipient Registration Form. There may be multiple fields per serology. Any evidence for a positive serology is treated as positive for that serology. CMV, cytomegalovirus; EBV, Epstein-Barr virus.
Donor Recipient CMV EBV
D- R- 33.4% 16.6%
D- R+ 16.1% 14.2%
D- R unk 0.8% 1.4%
D+ R- 28.3% 28.6%
D+ R+ 19.8% 36.9%
D+ R unk 0.8% 1.7%
D unk R- 0.6% 0.1%
D unk R+ 0.3% 0.4%
D unk R unk 0.0% 0.1%