Preface for OPTN/SRTR 2020 Annual Data Report
This Annual Data Report of the US Organ Procurement and Transplantation Network (OPTN) and the Scientific Registry of Transplant Recipients (SRTR) is the 30th annual report and is based on data pertaining to the period 2009-2020. The title OPTN/SRTR 2020 Annual Data Report reflects the fact that the report covers the most recent complete year of transplants, those performed in 2020.
This publication was developed for the US Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation, by the SRTR contractor, Hennepin Healthcare Research Institute (HHRI), and the OPTN contractor, United Network for Organ Sharing (UNOS), under SRTR contract HHSH75R60220C00011, and OPTN contract HHSH250201900001C.
As the SRTR contractor, HHRI, through its Chronic Disease Research Group (CDRG), determined which data to present, conducted the required analyses, created the figures and tables, and drafted the text. As the OPTN contractor, UNOS reviewed the draft report and contributed to the content. This report is available at http://srtr.transplant.hrsa.gov. Individual chapters, as well as the report as a whole, may be downloaded.
Overview and Highlights
This Annual Data Report includes chapters on kidney, pancreas, liver, intestine, heart, and lung transplants, as well as chapters on deceased organ donation, the SRTR Living Donor Collective, vascular composite allograft (VCA) transplant, and COVID-19. The organ-specific chapters include information on such topics as the waiting list, deceased donor organ donation, living donor organ donation, transplant, outcomes, and pediatric transplant. When possible, similar data and formats are used for each chapter. However, this is not always possible because some data are not pertinent to all organs.
Graphical presentation of the data is emphasized: more than 600 figures, tables, and maps are included in the chapters. They may be copied and pasted from the HTML files into slides.
Maps in this report present data divided into quintiles. Below is a sample map.
In this example, approximately one-fifth of all data points have a value of 72.5 or above. Ranges include the number at the lower end of the range and exclude that at the upper end (e.g., the second range here is 44.7 to < 56.1). Numbers in the first and last boxes are the minimum and maximum of observed data.
Maps by donation service area (DSA) use DSA boundaries in effect at the beginning of 2021, after the merger of LifeChoice Donor Services and New England Organ Bank. Some DSAs include non-contiguous areas. If a DSA has no transplant program for a given organ or no listings during the map's time frame, it is labeled ''No data'' on the map and shaded accordingly.
Milesone Dates in the Production of This Report
Data were cut: July 2021.
Data were analyzed: July 2021.
Methods
PRA and CPRA
For recipients of kidney and pancreas transplants performed on January 1, 2010 or later, panel-reactive antibody (PRA) at the time of transplant is the calculated PRA (cPRA) value. Before 2010, PRA was differentially available as cPRA and peak historical PRA. We chose to exclude 2008 and 2010 data from the graphs rather than use differently ascertained measures.
For liver, intestine, heart, and lung transplant recipients, PRA at the time of transplant is the value of the most recently recorded PRA. If that value is missing, we use the peak historical PRA value known at the time of transplant.
Heart status groups
On October 18, 2018, adult candidates were allocated hearts based on status groups 1-6. Status 1 candidates have the highest waitlist mortality risk and status 6 the lowest. Before that date, candidates were allocated hearts based on status groups 1A (highest priority), 1B, and 2. Because ADR data are reported annually, for the last 10 weeks of 2018, we converted new status groups 1-6 to old status groups 1A, 1B, and 2, according to the table below. Some former status 2 candidates were converted to new status 4 if they met all criteria, but most current status 4 candidates would have been status 1B under the old system. For 2019 and 2020, waitlist and recipient distributions by status groups 1-6 are given in separate figures.
Adult status group, 10/18/2018-12-31-2020 | Adult status group prior to 10/18/2018 |
---|---|
1 | 1A |
2 | 1A |
3 | 1A |
4 | 1B |
5 | B |
6 | B |
Incidence
Cumulative incidence of posttransplant outcomes (diabetes, posttransplant lymphoproliferative disorder, and acute rejection) are computed using survival methods.
Graft failure
Unless otherwise specified, ''graft failure'' refers to graft failure from any cause, including death and retransplant. For kidney failure, this also includes return to maintenance dialysis. ''Graft survival'' similarly refers to the absence of all-cause graft failure.
Patient survival
Posttransplant patient survival is not censored at graft failure. Thus, patient survival includes follow-up after graft failure, re-transplant, and return to maintenance dialysis in the case of kidney recipients.
Alive with function
Alive with function For a given year and organ type, counts of recipients alive with function include all recipients of that organ who underwent transplant before June 30 of the given year and who have no evidence of graft loss or death. Multi-organ recipients are counted once per organ. A heart-lung recipient, for example, is included in the counts of heart recipients and lung recipients alive with function. A kidney-alone recipient who underwent transplant in January 2001 and lost graft function in November 2010 is counted as alive with function in 2009 and 2010. Recipients lost to follow-up are assumed to be alive with a functioning graft until evidence, usually a death date, contradicts this assumption.
Transplant rates
In contrast to previous years, transplant rates include all waiting time (i.e., active and inactive) in the interval described.
Pretransplant mortality
Pretransplant mortality rates include all waiting time, and patients are followed until the earliest date of transplant, death, transfer to another program, removal from the waiting list due to improved condition, or cohort censor date. Because we continue to follow candidates for death outcomes beyond removal (except removal due to improved condition), we do not include removal due to deteriorated condition as part of a combined outcome.
Rates by subgroup
When rates are shown by subgroup (ie, sex, race, or primary cause of disease), the numerator and denominator are computed exclusively within those groups. For example, for pretransplant mortality by race, the numerator for each race is the number of deaths in that group during the interval described. The denominator is the total waiting time within each race group in that same time interval. When a characteristic is subject to change over time (eg, MELD, PRA), it is assessed at the later of January 1 of the year or the listing date, and a candidate contributes waiting time and outcome only at that level. For example, age is assessed only once a year; therefore, a candidate contributes all of his or her waiting time to a single age category in a given yearly rate calculation but may change age categories over time. For example, a waitlisted candidate who was 34 years old on January 1, 2012 would be included in the 18- to 34-year age group in 2012, but if that candidate was still listed in 2014, he or she would be included in the 35- to 49-year age group.
Donor Risk Index
The kidney donor risk index (KDRI) and pancreas donor risk index (PDRI) are measures of donor quality based on donor factors.
KDRI1=exp{-0.0194 x [if age < 18yrs] x [age - 18yrs] + 0.0128 x [age - 40yrs] + 0.0107 x [if age > 50yrs] x [age - 50yrs] + 0.179 x [if African-American] + 0.126 x [if hypertensive] + 0.130 x [if diabetic] + 0.220 x [serum creatitine -1mg/dL] - 0.209 x [if serum creatinine > 1.5mg/dL] x [serum creatinine - 1.5mg/dL] + 0.0881 x [if cause of death = cerebrovascular accident] - 0.0464 x [(height - 170cm)/10] - 0.0199 x [if weight < 80 kg] x [(weight-80kg)/5] + 0.133 x [if DCD] + 0.240 x [if HCV+]}
PDRI2=exp{-0.1379 x [if female] - 0.03446 x [if age < 20yrs] x [age - 20yrs] + 0.02615 x [age - 28yrs] + 0.1949 x [if creatinine > 2.5mg/dL] + 0.2395 x [if African-American race] + 0.1571 x [if Asian race] - 0.0009863 x [BMI - 24] + 0.03327 x [if BMI > 25] x [BMI - 25] - 0.006074 x [height - 173cm] + 0.3317 x [if DCD] + 0.2102 x [if cause of death = cerebrovascular accident]}
Complete versions of these indices also include transplant factors, but the donor-specific indices we show in this report are limited to donor-specific factors. To convert the KDRI to a cumulative percentage scale (i.e., the KDPI), we used a reference population of all deceased donor kidneys recovered for transplant in the United States in 2018. Kidneys recovered en bloc were counted once.
1Rao PS, Schaubel DE, Guidinger MK, Andreoni KA, Wolfe RA, Merion RM, Port FK, Sung RS. A comprehensive risk quantification score for deceased donor kidneys: the kidney donor risk index. Transplantation. 2009; 88(2): 231-236.
2Axelrod DA , Sung RS, Meyer KH, Wolfe RA , Kaufman DB. Systematic evaluation of pancreas allograft quality, outcomes and geographic variation in utilization. Am J Transplant. 2010; 10: 837-845.
Notes
Population Reported
Figure titles indicate adult or pediatric populations; if not specified, data include patients of all ages. In the past, lung data included patients 12 years or older with adults, and figure titles specified the age ranges. Since the 2019 report, we have classified all lung patients 18 years or older as adults and younger patients as pediatrics.
Unless otherwise specified, data in each organ-specific chapter include both isolated transplants and multi-organ transplants of the given type. For example, patients on the kidney transplant waiting list include those listed for an isolated kidney, kidney-pancreas, or any other organ combination that includes kidney.
Waitlist populations are no longer reported at the person level. If a patient is listed at more than one center, that patient is counted once per listing.
Age
Adult patients are defined as those aged 18 years or older for all organs. For waitlist figures, age is defined at the time of first listing, unless otherwise specified.
Race/ethnicity
Multiracial patients are defined as other/unknown. When a given race is not shown, it is included with other/unknown.
Pancreas data
Pancreas data encompass the three types of pancreas waiting lists or transplants: simultaneous kidney-pancreas (SPK), pancreas after kidney (PAK), and pancreas transplant alone (ie, without kidney; PTA). Pancreata used for islet transplant are excluded.
MELD Score
MELD scores shown in figures and tables are calculated MELD scores, not allocation MELD scores, unless otherwise specified.
Metropolitan and non-metropolitan designation
Many data are displayed by the designation of a candidate's or recipient's permanent ZIP code as metropolitan or non-metropolitan. We used Rural-Urban Commuting Area (RUCA) codes and defined metropolitan, micropolitan, small town, and rural areas. These were then collapsed into metropolitan areas, which include suburbs adjacent to major cities, and non-metropolitan, which include cities, towns, and rural areas of fewer than 50,000 people.
Data Requests
Requests for data can be made to SRTR at http://www.srtr.org or to OPTN at http://optn.transplant.hrsa.gov.
Websites
http://www.srtr.org is a public website containing transplant program-specific reports, organ procurement organization (OPO)-specific reports, summary tables, archives of past reports, timelines for future reports, risk-adjustment models, methods, basic references for researchers who use SRTR data files, links to current and past Annual Data Reports and their supporting documentation and data tables, answers to frequently asked questions, and other information.
https://securesrtr.transplant.hrsa.gov is a secure website that provides access to the prerelease program- and OPO-specific reports, survival spreadsheets, and other useful information. All individual authorized users from transplant programs and OPOs have their own unique logins for the secure site.
http://unos.org is a public website containing information on donation and transplantation, data collection instruments, data reports, education materials for patients and transplant professionals, policy development, and other information. This website also links to the OPTN website.
http://optn.transplant.hrsa.gov is a public website containing news, information, and resources about transplant and donation, including transplant data reports, policy development, and related boards and committees. It also contains allocation calculators, a calendar of events, answers to frequently asked questions, and other information.
Contact Information
Patient Inquiries
888-894-6361 (toll free)
Research Inquiries
OPTN/UNOS requests: 804-782-4876 (phone); 804-782-4994 (fax)
SRTR data requests: 877-970-SRTR (toll free); 612-873-1644 (fax)
Media Inquiries
301-443-3376 (HRSA/Office of Communications)
804-782-4730 (OPTN)
877-970-SRTR (SRTR)
Federal Program Inquiries
HHS/HRSA/HSB/DoT
5600 Fishers Lane
Parklawn Bldg, Eighth Floor West
Rockville, MD 20857
301-443-7577
Abbreviations
BMI | body mass index |
CAKUT | congenital anomalies of the kidney and urinary tract |
CDC | Centers for Disease Control and Prevention |
CDRG | Chronic Disease Research Group |
CKD | cystic kidney disease |
CMV | cytomegalovirus |
COPD | chronic obstructive pulmonary disease |
CPRA | calculated panel reactive antibody |
DBD | donation after brain death |
DCD | donation after circulatory death |
DD | deceased donor |
DM | diabetes mellitus |
DoT | Division of Transplantation |
DSA | donation service area |
EBV | Epstein-Barr virus |
ECD | expanded criteria donor |
ECMO | extracorporeal membrane oxygenation |
ESRD | end-stage renal disease |
eGFR | estimated glomerular filtration rate |
FSGS | focal segmental glomerulosclerosis |
GN | glomerulonephritis |
HHS | Health and Human Services |
HIV | human immunodeficiency virus |
HLA | human leukocyte antigen |
HMO | health maintenance organization |
HRSA | Health Resources and Services Administration |
HSB | Healthcare Systems Bureau |
HTN | hypertension |
ICU | intensive care unit |
KAS | kidney allocation system |
KDPI | kidney donor profile index |
KDRI | kidney donor risk index |
LAS | lung allocation score |
LD | living donor |
LVAD | left ventricular assist device |
MELD | model for end-stage liver disease |
mTOR | mammalian target of rapamycin |
OPO | organ procurement organization |
OPTN | Organ Procurement and Transplantation Network |
ORPD | organs recovered per donor |
OTPD | organs transplanted per donor |
PAK | pancreas after kidney transplant |
PELD | pediatric end-stage liver disease |
PDRI | pancreas donor risk index |
PRA | panel-reactive antibody |
PTA | pancreas transplant alone |
PTLD | posttransplant lymphoproliferative disorder |
SCD | standard criteria donor |
SGS | short-gut syndrome |
SPK | simultaneous pancreas-kidney transplant |
SRTR | Scientific Registry of Transplant Recipients |
TAH | total artificial heart |
UNOS | United Network for Organ Sharing |
VAD | ventricular assist device |
The publication was produced for the U.S. Department of Health and Human Services (HHS), Health Resources and Services Administration (HRSA), by Hennepin Healthcare Research Institute (HHRI) and the United Network for Organ Sharing (UNOS) under contracts HHSH75R60220C00011 and HHSH250201900001C, respectively.
This publication lists non-federal resources in order to provide additional information to consumers. The views and content in these resources have not been formally approved by HHS or HRSA. Neither HHS nor HRSA endorses the products or services of the listed resources.
The OPTN/SRTR 2020 Annual Data Report is not copyrighted. Readers are free to duplicate and use all or part of the information contained in this publication. Data are not copyrighted and may be used without permission if appropriate citation information is provided.
Pursuant to 42 U.S.C. § 1320b-10, this publication may not be reproduced, reprinted, or redistributed for a fee without specific written authorization from HHS.
Suggested Citations
Full citation: Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR). OPTN/SRTR 2020 Annual Data Report. Rockville, MD: Department of Health and Human Services, Health Resources and Services Administration; 2022.
Abbreviated citation: OPTN/SRTR 2020 Annual Data Report. HHS/HRSA.
Publications based on data in this report or supplied on request must include a citation and the following statement: The data and analyses reported in the 2020 Annual Data Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients have been supplied by the United Network for Organ Sharing and Hennepin Healthcare Research Institute under contract with HHS/HRSA. The authors alone are responsible for reporting and interpreting these data; the views expressed herein are those of the authors and not necessarily those of the U.S. government.
This report is available at http://srtr.transplant.hrsa.gov. Individual chapters, as well as the report as a whole, may be downloaded.