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Table 10.6f

Immunosuppression Use for Maintenance by Regimen

One Year Following Transplantation, 1999 to 2008

Recipients with Intestine Transplants

  Transplant Year
1999 2000 2001 2002 2003 2004 2005 2006 2007 2008
Transplants 73 82 113 107 116 152 178 175 198 185
Functioning Graft at 1 Year PostTx 37 55 69 73 88 113 130 120 139 138
With Maintenance Use Recorded at 1 Year PostTx 36 55 69 70 87 112 130 120 139 137
CyA 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.8% 0.7% 0.0%
Tac 2.8% 3.6% 26.1% 21.4% 39.1% 29.5% 37.7% 33.3% 27.3% 27.0%
Tac + MMF/MPA 0.0% 0.0% 0.0% 0.0% 1.1% 0.0% 1.5% 0.0% 2.9% 2.2%
Tac + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 2.7% 1.5% 0.0% 0.0% 0.0%
--- + Siro/Evero 0.0% 0.0% 1.4% 1.4% 1.1% 0.9% 0.8% 0.8% 0.0% 0.7%
Tac + Siro/Evero 2.8% 0.0% 1.4% 1.4% 1.1% 4.5% 2.3% 3.3% 0.7% 1.5%
--- + MMF/MPA + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.8% 0.0% 0.0% 0.0%
Tac + MMF/MPA + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.8% 0.8% 0.0% 0.0%
--- + Steroids 0.0% 1.8% 0.0% 1.4% 3.4% 1.8% 0.8% 0.0% 0.7% 0.7%
CyA + Steroids 0.0% 0.0% 0.0% 0.0% 0.0% 0.9% 1.5% 0.8% 0.0% 0.7%
Tac + Steroids 61.1% 61.8% 58.0% 47.1% 41.4% 40.2% 35.4% 46.7% 54.0% 48.2%
--- + MMF/MPA + Steroids 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.7%
Tac + MMF/MPA + Steroids 11.1% 9.1% 2.9% 4.3% 6.9% 6.3% 3.8% 5.0% 5.8% 10.9%
Tac + OtherAntimet + Steroids 11.1% 0.0% 2.9% 0.0% 0.0% 1.8% 1.5% 0.8% 1.4% 0.7%
--- + Siro/Evero + Steroids 0.0% 1.8% 0.0% 0.0% 1.1% 3.6% 0.0% 0.0% 1.4% 0.0%
Tac + Siro/Evero + Steroids 8.3% 21.8% 7.2% 21.4% 4.6% 8.0% 11.5% 7.5% 3.6% 6.6%
Other Regimen 2.8% 0.0% 0.0% 1.4% 0.0% 0.0% 0.0% 0.0% 1.4% 0.0%


Source: OPTN/SRTR Data as of October 1, 2010.

Percentages are calculated based on the total number of patients with maintenance use at one year following transplantation. They sum to 100 percent for each column.

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.