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Table 11.6f

Immunosuppression Use for Maintenance by Regimen

One Year Following Transplantation, 1999 to 2008

Recipients with Heart Transplants

  Transplant Year
1999 2000 2001 2002 2003 2004 2005 2006 2007 2008
Transplants 2,188 2,199 2,202 2,155 2,057 2,015 2,125 2,193 2,209 2,163
Functioning Graft at 1 Year PostTx 1,781 1,820 1,850 1,823 1,756 1,748 1,807 1,896 1,927 1,871
With Maintenance Use Recorded at 1 Year PostTx 1,725 1,755 1,829 1,787 1,719 1,739 1,795 1,877 1,898 1,783
CyA 0.9% 1.3% 0.8% 0.8% 0.8% 0.3% 0.3% 0.3% 0.4% 0.4%
Tac 1.3% 1.1% 0.7% 1.6% 1.3% 1.2% 2.4% 2.8% 2.6% 4.0%
--- + MMF/MPA 0.1% 0.2% 0.1% 0.2% 0.4% 0.2% 0.1% 0.2% 0.2% 0.4%
CyA + MMF/MPA 8.5% 9.7% 9.0% 8.6% 8.5% 8.3% 7.6% 6.7% 5.3% 4.9%
Tac + MMF/MPA 2.8% 3.4% 6.9% 6.3% 10.4% 10.8% 15.4% 16.6% 20.0% 24.2%
--- + OtherAntimet 0.2% 0.2% 0.1% 0.0% 0.1% 0.0% 0.0% 0.0% 0.0% 0.1%
CyA + OtherAntimet 3.3% 2.3% 1.6% 2.4% 1.2% 1.4% 0.7% 1.1% 0.8% 0.8%
Tac + OtherAntimet 0.9% 0.9% 0.9% 1.1% 1.0% 1.3% 1.1% 1.2% 1.9% 2.2%
--- + MMF/MPA + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.0% 0.1% 0.0% 0.0%
CyA + MMF/MPA + OtherAntimet 0.0% 0.0% 0.1% 0.1% 0.0% 0.1% 0.1% 0.0% 0.0% 0.0%
Tac + MMF/MPA + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.2% 0.0% 0.0% 0.0%
--- + Siro/Evero 0.0% 0.0% 0.1% 0.0% 0.2% 0.0% 0.0% 0.0% 0.1% 0.2%
CyA + Siro/Evero 0.1% 0.1% 0.2% 0.8% 0.8% 0.5% 0.2% 0.4% 0.4% 0.3%
Tac + Siro/Evero 0.0% 0.2% 0.2% 1.3% 1.5% 0.9% 1.5% 1.2% 1.1% 1.1%
--- + MMF/MPA + Siro/Evero 0.0% 0.0% 0.1% 0.1% 0.2% 0.2% 0.7% 0.5% 0.4% 0.3%
CyA + MMF/MPA + Siro/Evero 0.1% 0.1% 0.1% 0.2% 0.5% 0.1% 0.2% 0.1% 0.2% 0.3%
Tac + MMF/MPA + Siro/Evero 0.1% 0.0% 0.1% 0.3% 0.2% 0.3% 0.3% 0.5% 0.5% 0.6%
--- + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.1% 0.1% 0.1% 0.0% 0.1% 0.0%
CyA + OtherAntimet + Siro/Evero 0.1% 0.0% 0.0% 0.1% 0.0% 0.1% 0.0% 0.1% 0.0% 0.0%
Tac + OtherAntimet + Siro/Evero 0.0% 0.1% 0.0% 0.1% 0.0% 0.1% 0.0% 0.1% 0.0% 0.0%
--- + Steroids 2.0% 2.2% 3.4% 0.4% 0.2% 0.4% 0.1% 0.2% 0.1% 0.4%
CyA + Steroids 4.9% 3.6% 1.9% 1.9% 1.9% 0.9% 1.4% 1.1% 1.0% 0.8%
Tac + Steroids 2.3% 2.3% 4.3% 3.5% 3.1% 2.6% 2.8% 2.7% 2.5% 4.5%
--- + MMF/MPA + Steroids 0.5% 0.8% 0.5% 0.6% 0.3% 0.6% 0.4% 0.3% 0.3% 0.7%
CyA + MMF/MPA + Steroids 35.1% 41.0% 33.5% 27.8% 24.8% 23.6% 20.7% 18.6% 16.1% 11.2%
Tac + MMF/MPA + Steroids 14.6% 16.9% 21.2% 24.9% 25.8% 32.1% 33.5% 35.4% 36.5% 33.9%
--- + OtherAntimet + Steroids 0.1% 0.1% 0.2% 0.1% 0.1% 0.0% 0.0% 0.0% 0.0% 0.0%
CyA + OtherAntimet + Steroids 11.3% 6.6% 4.6% 3.2% 2.0% 2.8% 0.9% 1.1% 0.6% 0.3%
Tac + OtherAntimet + Steroids 3.4% 1.9% 2.6% 1.9% 2.0% 1.6% 1.3% 1.5% 1.6% 2.0%
--- + Siro/Evero + Steroids 0.1% 0.2% 0.4% 0.3% 0.2% 0.1% 0.2% 0.2% 0.3% 0.2%
CyA + Siro/Evero + Steroids 1.2% 1.3% 0.8% 1.2% 2.5% 1.0% 0.6% 2.1% 2.4% 1.6%
Tac + Siro/Evero + Steroids 0.5% 1.0% 2.8% 4.5% 4.4% 2.2% 2.1% 1.5% 0.9% 1.5%
Other Regimen 5.9% 2.7% 3.1% 6.0% 5.5% 6.3% 5.1% 3.5% 3.8% 3.4%


Source: OPTN/SRTR Data as of October 1, 2010.

Percentages are calculated based on the total number of patients with maintenance use at one year following transplantation. They sum to 100 percent for each column.

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.