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Table 12.6f

Immunosuppression Use for Maintenance by Regimen

One Year Following Transplantation, 1999 to 2008

Recipients with Lung Transplants

  Transplant Year
1999 2000 2001 2002 2003 2004 2005 2006 2007 2008
Transplants 922 977 1,083 1,054 1,099 1,185 1,407 1,406 1,471 1,478
Functioning Graft at 1 Year PostTx 668 735 805 834 901 985 1,132 1,156 1,161 1,200
With Maintenance Use Recorded at 1 Year PostTx 621 695 767 810 869 976 1,118 1,142 1,150 1,145
CyA 0.0% 0.4% 0.0% 0.1% 0.0% 0.0% 0.0% 0.2% 0.1% 0.1%
Tac 0.2% 0.0% 0.3% 0.6% 0.3% 0.1% 0.0% 0.3% 0.3% 0.0%
--- + MMF/MPA 0.3% 0.1% 0.0% 0.0% 0.0% 0.0% 0.0% 0.2% 0.0% 0.0%
CyA + MMF/MPA 0.0% 0.1% 0.4% 0.1% 0.3% 0.0% 0.1% 0.2% 0.0% 0.2%
Tac + MMF/MPA 0.3% 1.3% 0.5% 1.0% 0.5% 0.4% 0.5% 1.2% 0.6% 0.7%
--- + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.1% 0.0% 0.0% 0.0% 0.0% 0.0%
CyA + OtherAntimet 0.2% 0.1% 0.1% 0.4% 0.2% 0.0% 0.0% 0.1% 0.0% 0.0%
Tac + OtherAntimet 0.2% 0.1% 0.1% 1.2% 0.5% 0.2% 0.1% 0.2% 0.2% 0.0%
CyA + MMF/MPA + OtherAntimet 0.0% 0.1% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
Tac + MMF/MPA + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.0% 0.0%
--- + Siro/Evero 0.3% 0.0% 0.3% 0.1% 0.1% 0.0% 0.0% 0.0% 0.0% 0.0%
CyA + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.0% 0.0%
Tac + Siro/Evero 0.2% 0.1% 0.1% 0.2% 0.1% 0.0% 0.1% 0.1% 0.0% 0.0%
--- + MMF/MPA + Siro/Evero 0.0% 0.0% 0.1% 0.1% 0.0% 0.0% 0.1% 0.0% 0.1% 0.0%
Tac + MMF/MPA + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.1% 0.0% 0.1% 0.1% 0.1% 0.0%
--- + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.2% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
Tac + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.1% 0.1% 0.0% 0.0% 0.0% 0.0%
--- + Steroids 0.5% 0.4% 0.5% 0.4% 0.7% 0.4% 0.4% 0.4% 0.3% 1.3%
CyA + Steroids 5.6% 3.5% 2.1% 1.6% 2.3% 1.1% 1.3% 1.5% 2.3% 2.4%
Tac + Steroids 6.4% 5.5% 9.9% 7.3% 8.2% 9.9% 9.6% 8.5% 13.2% 15.5%
--- + MMF/MPA + Steroids 0.0% 0.4% 0.3% 0.1% 0.3% 0.2% 0.2% 0.4% 0.3% 0.3%
CyA + MMF/MPA + Steroids 17.4% 14.0% 14.0% 10.7% 8.9% 7.6% 7.6% 4.1% 3.7% 4.3%
Tac + MMF/MPA + Steroids 17.2% 26.6% 29.7% 32.7% 34.1% 40.9% 45.9% 47.7% 48.7% 48.1%
--- + OtherAntimet + Steroids 0.2% 0.4% 0.3% 0.2% 0.3% 0.1% 0.1% 0.4% 0.2% 0.5%
CyA + OtherAntimet + Steroids 26.7% 22.9% 12.4% 8.1% 8.9% 6.1% 4.9% 4.6% 2.9% 2.3%
Tac + OtherAntimet + Steroids 17.4% 16.3% 17.3% 20.1% 22.8% 23.0% 20.4% 22.2% 18.5% 17.1%
--- + Siro/Evero + Steroids 0.0% 0.0% 0.1% 0.7% 0.2% 0.2% 0.4% 0.1% 0.1% 0.2%
CyA + Siro/Evero + Steroids 1.8% 1.3% 0.9% 0.9% 0.5% 0.3% 0.1% 0.4% 0.1% 0.3%
Tac + Siro/Evero + Steroids 3.2% 2.7% 3.5% 6.3% 4.0% 4.2% 3.8% 3.4% 2.8% 2.2%
Other Regimen 1.9% 3.5% 7.0% 6.5% 6.4% 5.1% 4.5% 3.8% 5.7% 4.5%


Source: OPTN/SRTR Data as of October 1, 2010.

Percentages are calculated based on the total number of patients with maintenance use at one year following transplantation. They sum to 100 percent for each column.

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.