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Table 12.6h

Persistency of Discharge Regimen by Follow-up Period, 2004 to 2008

Recipients with Lung Transplants

  Year of Transplant
2004 2005 2006 2007 2008
Discharge Regimen (w/ or w/o Steroid Use) CyA+Aza At Discharge (N) 179 155 95 90 51
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 55.9% 77.4% 74.7% 84.4% 51.5%
2 Years PostTx (%) 26.3% 31.6% 34.2% 24.0% 12.7%
3 Years PostTx (%) 16.8% 24.9% 17.7% 16.0% -
CyA+MMF At Discharge (N) 111 102 84 31 40
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 58.6% 71.6% 56.0% 41.9% 60.3%
2 Years PostTx (%) 34.5% 47.1% 35.7% 19.4% 37.5%
3 Years PostTx (%) 26.7% 31.9% 29.4% 0.0% -
Siro+MMF At Discharge (N) 4 2 1 1 1
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 25.0% 50.0% 0.0% 0.0% 0.0%
2 Years PostTx (%) 25.0% 50.0% 0.0% 0.0% 0.0%
3 Years PostTx (%) 25.0% 50.0% 0.0% 0.0% 0.0%
Tac+Aza At Discharge (N) 274 314 370 322 315
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 67.0% 64.5% 75.6% 67.6% 62.0%
2 Years PostTx (%) 46.9% 46.8% 48.6% 48.8% 41.2%
3 Years PostTx (%) 34.5% 36.2% 38.6% 35.5% -
Tac+MMF At Discharge (N) 394 569 611 773 807
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 84.1% 78.3% 82.8% 75.6% 71.5%
2 Years PostTx (%) 69.3% 64.0% 68.5% 58.8% 55.0%
3 Years PostTx (%) 58.8% 53.8% 56.9% 46.5% -
Tac+Siro At Discharge (N) 4 3 11 2 2
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 75.0% 66.7% 90.9% 100.0% 50.0%
2 Years PostTx (%) 50.0% 33.3% 54.5% 100.0% -
3 Years PostTx (%) 50.0% 0.0% 45.5% 100.0% -


Source: OPTN/SRTR Data as of October 1, 2010.

Regimen change is defined as being on different drug combination at follow-up comparing to discharge, or indication of conflicting regimen

(CyA vs. Tac; MMF/MPA vs. Aza; Siro vs. Evero) during follow-up period, or graft failure/death. Addition or deletion of steroids is not considered a regimen change.&

Rates are calculated for the most common discharge regimens.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.

See Technical Notes for further details.