Table 15.8

Immunosuppression Use for Maintenance by Regimen

Two Years Following Transplantation, 1999 to 2007

Recipients with Pancreas Transplant Alone (PTA) Transplants

	Transplant Year
	1999	2000	2001	2002	2003	2004	2005	2006	2007
Transplants	139	134	168	180	160	183	199	174	210
Functioning Graft at 2 Years PostTx	91	82	112	114	88	116	137	108	134
With Maintenance Use Recorded at 2 Years PostTx	82	80	111	114	88	115	131	101	110
CyA	0.0%	0.0%	0.0%	0.0%	1.1%	0.0%	0.0%	0.0%	0.0%
Tac	0.0%	3.8%	8.1%	5.3%	21.6%	16.5%	22.9%	22.8%	12.7%
--- + MMF/MPA	0.0%	0.0%	0.9%	1.8%	0.0%	1.7%	0.0%	0.0%	0.0%
CyA + MMF/MPA	1.2%	0.0%	0.9%	1.8%	1.1%	0.9%	0.0%	1.0%	0.0%
Tac + MMF/MPA	4.9%	2.5%	5.4%	16.7%	17.0%	12.2%	24.4%	14.9%	18.2%
CyA + OtherAntimet	0.0%	0.0%	0.0%	0.9%	0.0%	0.0%	0.0%	0.0%	0.0%
Tac + OtherAntimet	0.0%	0.0%	0.0%	0.0%	1.1%	0.9%	0.0%	1.0%	0.9%
--- + Siro/Evero	0.0%	0.0%	0.0%	0.9%	2.3%	1.7%	0.0%	0.0%	0.9%
CyA + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.8%	1.0%	0.0%
Tac + Siro/Evero	2.4%	5.0%	2.7%	8.8%	6.8%	9.6%	7.6%	5.0%	2.7%
--- + MMF/MPA + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.0%	0.9%	0.8%	1.0%	2.7%
CyA + MMF/MPA + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.9%
Tac + MMF/MPA + Siro/Evero	0.0%	0.0%	0.0%	0.9%	2.3%	3.5%	3.1%	12.9%	9.1%
--- + Steroids	0.0%	0.0%	0.9%	0.0%	0.0%	0.9%	0.0%	0.0%	0.9%
CyA + Steroids	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	1.0%	0.0%
Tac + Steroids	9.8%	10.0%	17.1%	11.4%	6.8%	13.9%	9.2%	15.8%	27.3%
--- + MMF/MPA + Steroids	0.0%	0.0%	1.8%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%
CyA + MMF/MPA + Steroids	7.3%	8.8%	3.6%	2.6%	3.4%	0.9%	0.0%	0.0%	0.0%
Tac + MMF/MPA + Steroids	56.1%	41.3%	45.9%	32.5%	27.3%	27.8%	25.2%	20.8%	20.9%
--- + OtherAntimet + Steroids	0.0%	0.0%	0.0%	0.0%	0.0%	0.9%	0.0%	0.0%	0.0%
Tac + OtherAntimet + Steroids	4.9%	3.8%	0.9%	0.9%	0.0%	1.7%	0.0%	1.0%	0.0%
--- + Siro/Evero + Steroids	3.7%	1.3%	0.0%	0.9%	0.0%	1.7%	0.0%	0.0%	0.0%
CyA + Siro/Evero + Steroids	1.2%	1.3%	0.0%	0.9%	1.1%	0.0%	0.0%	0.0%	0.0%
Tac + Siro/Evero + Steroids	8.5%	16.3%	9.9%	11.4%	3.4%	1.7%	4.6%	1.0%	0.0%
Other Regimen	0.0%	6.3%	1.8%	2.6%	4.5%	2.6%	1.5%	1.0%	2.7%

Source: OPTN/SRTR Data as of October 1, 2010.

Percentages are calculated based on the total number of patients with maintenance use at two years following transplantation. They sum to 100 percent for each column

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.