Table 15.9

Immunosuppression Use for Maintenance by Regimen

Two Years Following Transplantation, 1999 to 2007

Recipients with Pancreas After Kidney (PAK) Transplants

	Transplant Year
	1999	2000	2001	2002	2003	2004	2005	2006	2007
Transplants	220	305	305	375	344	420	343	293	261
Functioning Graft at 2 Years PostTx	145	196	223	250	219	280	224	203	199
With Maintenance Use Recorded at 2 Years PostTx	138	185	217	247	215	275	201	174	158
Tac	0.0%	0.0%	0.9%	1.2%	1.9%	3.6%	3.0%	1.7%	1.3%
--- + MMF/MPA	0.0%	0.0%	0.9%	0.8%	2.8%	2.5%	0.0%	0.0%	0.0%
CyA + MMF/MPA	0.0%	0.0%	1.4%	1.2%	1.4%	1.1%	1.0%	1.1%	1.3%
Tac + MMF/MPA	3.6%	4.9%	6.5%	4.9%	9.3%	13.8%	16.9%	22.4%	26.6%
CyA + OtherAntimet	0.0%	0.0%	0.0%	0.0%	0.5%	0.0%	0.0%	0.0%	0.0%
Tac + OtherAntimet	0.7%	0.0%	0.0%	0.0%	0.5%	0.0%	0.5%	0.0%	0.6%
--- + Siro/Evero	0.0%	0.0%	0.5%	0.0%	0.9%	0.0%	0.0%	0.0%	0.0%
CyA + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.0%	0.4%	0.0%	2.3%	0.6%
Tac + Siro/Evero	0.0%	1.6%	6.9%	5.7%	6.0%	8.0%	5.0%	2.9%	4.4%
--- + MMF/MPA + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.5%	0.4%	2.0%	1.7%	0.6%
Tac + MMF/MPA + Siro/Evero	0.0%	0.0%	0.0%	0.0%	1.9%	0.4%	2.0%	2.9%	5.7%
--- + Steroids	0.0%	0.0%	1.4%	0.0%	0.0%	0.0%	0.5%	0.0%	0.0%
CyA + Steroids	0.0%	1.6%	0.9%	0.4%	0.9%	0.0%	0.0%	0.0%	0.0%
Tac + Steroids	5.1%	6.5%	3.7%	4.5%	3.7%	3.3%	3.5%	5.7%	5.1%
--- + MMF/MPA + Steroids	0.7%	1.1%	1.4%	0.0%	0.9%	0.0%	0.0%	0.0%	1.3%
CyA + MMF/MPA + Steroids	9.4%	7.6%	4.6%	9.3%	5.1%	4.4%	2.5%	2.9%	1.3%
Tac + MMF/MPA + Steroids	67.4%	52.4%	47.9%	51.8%	43.3%	46.5%	49.8%	47.7%	42.4%
--- + OtherAntimet + Steroids	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.6%	0.0%
CyA + OtherAntimet + Steroids	0.7%	1.1%	0.9%	0.4%	0.0%	0.0%	0.5%	0.0%	0.0%
Tac + OtherAntimet + Steroids	4.3%	2.2%	0.5%	1.2%	1.9%	1.5%	2.5%	1.7%	2.5%
--- + Siro/Evero + Steroids	0.0%	0.0%	0.5%	1.6%	0.5%	0.4%	0.0%	0.6%	0.0%
CyA + Siro/Evero + Steroids	1.4%	2.2%	1.8%	1.6%	0.9%	0.7%	0.5%	0.6%	0.0%
Tac + Siro/Evero + Steroids	3.6%	13.5%	13.4%	10.1%	10.2%	6.9%	5.5%	3.4%	1.9%
Other Regimen	2.9%	5.4%	6.0%	5.3%	7.0%	6.2%	4.5%	1.7%	4.4%

Source: OPTN/SRTR Data as of October 1, 2010.

Percentages are calculated based on the total number of patients with maintenance use at two years following transplantation. They sum to 100 percent for each column

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.