Table 15.10

Immunosuppression Use for Maintenance by Regimen

Two Years Following Transplantation, 1999 to 2007

Recipients with Kidney-Pancreas Transplants

	Transplant Year
	1999	2000	2001	2002	2003	2004	2005	2006	2007
Transplants	941	915	891	906	871	881	903	924	864
Functioning Graft at 2 Years PostTx	815	797	748	779	746	752	785	781	749
With Maintenance Use Recorded at 2 Years PostTx	784	781	721	768	736	742	654	561	553
CyA	0.0%	0.0%	0.1%	0.4%	0.0%	0.0%	0.2%	0.2%	0.0%
Tac	0.1%	0.3%	1.8%	2.5%	1.4%	1.5%	2.3%	3.0%	1.4%
--- + MMF/MPA	0.0%	0.0%	0.1%	0.0%	0.3%	0.4%	0.0%	0.2%	0.2%
CyA + MMF/MPA	0.0%	0.0%	0.3%	0.3%	0.4%	0.4%	0.8%	0.9%	0.7%
Tac + MMF/MPA	2.4%	3.7%	5.3%	6.0%	7.3%	13.7%	15.6%	17.5%	20.1%
CyA + OtherAntimet	0.0%	0.1%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%
Tac + OtherAntimet	0.5%	0.1%	0.0%	0.3%	0.1%	0.4%	0.2%	0.0%	0.0%
Tac + MMF/MPA + OtherAntimet	0.0%	0.1%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.2%
--- + Siro/Evero	0.0%	0.0%	0.1%	0.4%	0.1%	0.1%	0.2%	0.4%	0.4%
CyA + Siro/Evero	0.1%	0.1%	0.3%	0.3%	1.2%	1.9%	2.3%	2.9%	2.5%
Tac + Siro/Evero	0.4%	3.3%	7.6%	8.2%	9.4%	5.8%	7.0%	2.9%	2.5%
--- + MMF/MPA + Siro/Evero	0.0%	0.0%	0.4%	0.3%	1.8%	4.6%	1.7%	1.1%	0.9%
CyA + MMF/MPA + Siro/Evero	0.1%	0.3%	0.0%	0.0%	0.0%	0.1%	0.2%	0.0%	0.0%
Tac + MMF/MPA + Siro/Evero	0.0%	0.3%	1.0%	0.4%	1.1%	0.9%	0.9%	3.6%	3.6%
--- + Steroids	0.3%	0.0%	0.8%	0.8%	0.5%	0.1%	0.2%	0.4%	0.5%
CyA + Steroids	1.0%	1.3%	1.0%	0.1%	0.4%	0.4%	0.2%	0.7%	0.4%
Tac + Steroids	7.5%	6.0%	5.1%	4.9%	4.8%	2.7%	4.1%	6.4%	5.2%
--- + MMF/MPA + Steroids	0.5%	0.3%	0.8%	0.9%	0.0%	1.1%	0.2%	0.0%	0.0%
CyA + MMF/MPA + Steroids	19.4%	11.0%	9.3%	8.3%	7.3%	3.4%	3.2%	1.6%	3.3%
Tac + MMF/MPA + Steroids	55.9%	53.1%	46.9%	49.1%	51.2%	52.0%	52.3%	49.6%	50.8%
--- + OtherAntimet + Steroids	0.0%	0.0%	0.0%	0.0%	0.0%	0.1%	0.0%	0.0%	0.0%
CyA + OtherAntimet + Steroids	0.1%	0.1%	0.1%	0.4%	0.0%	0.3%	0.0%	0.0%	0.4%
Tac + OtherAntimet + Steroids	3.3%	2.8%	0.8%	2.5%	1.9%	1.5%	1.5%	1.4%	2.4%
--- + Siro/Evero + Steroids	0.6%	0.5%	0.3%	0.4%	0.7%	0.1%	0.6%	0.0%	0.7%
CyA + Siro/Evero + Steroids	0.9%	2.6%	2.6%	0.9%	1.5%	0.3%	0.3%	0.4%	0.5%
Tac + Siro/Evero + Steroids	2.0%	6.4%	11.2%	8.7%	5.0%	5.4%	3.8%	3.7%	1.6%
Other Regimen	4.7%	7.6%	3.9%	4.0%	3.5%	2.7%	2.4%	3.4%	1.6%

Source: OPTN/SRTR Data as of October 1, 2010.

Percentages are calculated based on the total number of patients with maintenance use at two years following transplantation. They sum to 100 percent for each column

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.