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Table 15.12

Immunosuppression Use for Maintenance by Regimen

Two Years Following Transplantation, 1999 to 2007

Recipients with Intestine Transplants

  Transplant Year
1999 2000 2001 2002 2003 2004 2005 2006 2007
Transplants 73 82 113 107 116 152 178 175 198
Functioning Graft at 2 Years PostTx 30 47 59 64 76 105 112 108 114
With Maintenance Use Recorded at 2 Years PostTx 30 47 59 64 76 104 103 91 87
CyA 0.0% 0.0% 0.0% 0.0% 1.3% 0.0% 0.0% 0.0% 0.0%
Tac 3.3% 6.4% 28.8% 20.3% 42.1% 35.6% 41.7% 38.5% 32.2%
Tac + MMF/MPA 3.3% 0.0% 0.0% 1.6% 1.3% 1.0% 0.0% 2.2% 3.4%
Tac + OtherAntimet 0.0% 0.0% 0.0% 0.0% 1.3% 1.0% 1.9% 1.1% 0.0%
--- + Siro/Evero 0.0% 0.0% 0.0% 1.6% 0.0% 1.0% 1.9% 0.0% 0.0%
CyA + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 1.0% 0.0% 0.0%
Tac + Siro/Evero 6.7% 4.3% 3.4% 3.1% 2.6% 5.8% 1.9% 4.4% 1.1%
--- + Steroids 0.0% 4.3% 0.0% 3.1% 1.3% 1.0% 0.0% 0.0% 1.1%
CyA + Steroids 0.0% 0.0% 0.0% 0.0% 1.3% 0.0% 1.0% 1.1% 0.0%
Tac + Steroids 63.3% 53.2% 57.6% 50.0% 34.2% 36.5% 31.1% 40.7% 50.6%
Tac + MMF/MPA + Steroids 0.0% 2.1% 0.0% 7.8% 5.3% 5.8% 2.9% 7.7% 5.7%
Tac + OtherAntimet + Steroids 3.3% 0.0% 1.7% 0.0% 1.3% 1.9% 1.0% 0.0% 2.3%
--- + Siro/Evero + Steroids 0.0% 0.0% 0.0% 1.6% 0.0% 2.9% 1.9% 0.0% 0.0%
Tac + Siro/Evero + Steroids 16.7% 29.8% 8.5% 10.9% 7.9% 7.7% 13.6% 4.4% 2.3%
Other Regimen 3.3% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 1.1%


Source: OPTN/SRTR Data as of October 1, 2010.

Percentages are calculated based on the total number of patients with maintenance use at two years following transplantation. They sum to 100 percent for each column

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.