Flash e-reader

 Go to e-reader chapter








Table 15.14

Immunosuppression Use for Maintenance by Regimen

Two Years Following Transplantation, 1999 to 2007

Recipients with Lung Transplants

  Transplant Year
1999 2000 2001 2002 2003 2004 2005 2006 2007
Transplants 922 977 1,083 1,054 1,099 1,185 1,407 1,406 1,471
Functioning Graft at 2 Years PostTx 583 658 719 752 791 872 994 1,023 1,004
With Maintenance Use Recorded at 2 Years PostTx 551 614 680 735 780 861 850 860 860
CyA 0.2% 0.0% 0.1% 0.1% 0.0% 0.0% 0.0% 0.0% 0.0%
Tac 0.2% 0.0% 0.3% 0.1% 0.4% 0.2% 0.1% 0.1% 0.2%
--- + MMF/MPA 0.0% 0.2% 0.1% 0.1% 0.0% 0.1% 0.0% 0.0% 0.5%
CyA + MMF/MPA 0.2% 0.0% 0.3% 0.0% 0.1% 0.0% 0.0% 0.0% 0.0%
Tac + MMF/MPA 0.2% 0.3% 0.7% 0.5% 0.5% 0.7% 1.1% 0.9% 0.5%
--- + OtherAntimet 0.4% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
CyA + OtherAntimet 0.2% 0.2% 0.1% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
Tac + OtherAntimet 0.5% 0.2% 0.6% 1.0% 0.5% 0.1% 0.1% 0.0% 0.0%
--- + Siro/Evero 0.0% 0.0% 0.3% 0.0% 0.1% 0.0% 0.1% 0.0% 0.0%
CyA + Siro/Evero 0.2% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
Tac + Siro/Evero 0.2% 0.2% 0.3% 0.1% 0.5% 0.1% 0.2% 0.2% 0.1%
--- + MMF/MPA + Siro/Evero 0.0% 0.0% 0.0% 0.1% 0.1% 0.0% 0.1% 0.0% 0.1%
Tac + MMF/MPA + Siro/Evero 0.0% 0.3% 0.1% 0.1% 0.1% 0.0% 0.0% 0.0% 0.0%
--- + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.1% 0.1% 0.0% 0.0% 0.0% 0.0%
Tac + OtherAntimet + Siro/Evero 0.0% 0.0% 0.1% 0.1% 0.0% 0.0% 0.0% 0.1% 0.0%
--- + Steroids 0.7% 0.3% 0.6% 0.0% 0.6% 0.3% 0.2% 0.0% 0.3%
CyA + Steroids 4.9% 2.6% 1.2% 1.9% 1.7% 0.5% 2.0% 1.6% 2.1%
Tac + Steroids 5.1% 7.5% 8.1% 9.1% 9.6% 11.1% 10.9% 9.5% 12.8%
--- + MMF/MPA + Steroids 0.4% 0.5% 0.4% 0.5% 0.1% 0.2% 0.2% 0.1% 0.0%
CyA + MMF/MPA + Steroids 14.3% 14.7% 12.1% 8.8% 8.3% 5.5% 4.6% 4.5% 5.5%
Tac + MMF/MPA + Steroids 23.4% 27.9% 32.8% 35.1% 33.7% 41.8% 42.6% 47.1% 47.4%
--- + OtherAntimet + Steroids 0.2% 0.2% 0.3% 0.3% 0.1% 0.1% 0.1% 0.0% 0.1%
CyA + OtherAntimet + Steroids 22.1% 16.6% 7.5% 6.3% 7.6% 5.3% 4.5% 4.3% 2.0%
Tac + OtherAntimet + Steroids 16.3% 17.1% 17.4% 20.8% 20.6% 20.9% 18.6% 20.1% 15.9%
--- + Siro/Evero + Steroids 0.2% 0.2% 0.1% 0.4% 0.3% 0.5% 0.9% 0.3% 0.3%
CyA + Siro/Evero + Steroids 0.9% 1.3% 1.3% 0.7% 0.9% 0.3% 0.1% 0.2% 0.6%
Tac + Siro/Evero + Steroids 4.9% 4.4% 5.4% 6.3% 5.9% 4.9% 5.8% 4.2% 3.8%
Other Regimen 4.4% 5.5% 9.6% 7.2% 7.9% 7.2% 7.6% 6.5% 7.7%


Source: OPTN/SRTR Data as of October 1, 2010.

Percentages are calculated based on the total number of patients with maintenance use at two years following transplantation. They sum to 100 percent for each column

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.