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Table 15.15

Immunosuppression Use for Maintenance by Regimen

Two Years Following Transplantation, 1999 to 2007

Recipients with Heart-Lung Transplants

  Transplant Year
1999 2000 2001 2002 2003 2004 2005 2006 2007
Transplants 51 48 27 33 29 40 35 31 31
Functioning Graft at 2 Years PostTx 22 26 18 18 12 29 24 16 24
With Maintenance Use Recorded at 2 Years PostTx 22 24 16 18 12 28 23 14 23
Tac 0.0% 4.2% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 4.3%
Tac + MMF/MPA 0.0% 4.2% 6.3% 0.0% 8.3% 0.0% 4.3% 0.0% 0.0%
--- + OtherAntimet 0.0% 4.2% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
Tac + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 4.3% 0.0% 0.0%
CyA + Steroids 9.1% 8.3% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
Tac + Steroids 0.0% 4.2% 25.0% 11.1% 0.0% 7.1% 13.0% 21.4% 30.4%
CyA + MMF/MPA + Steroids 9.1% 16.7% 6.3% 16.7% 8.3% 10.7% 8.7% 0.0% 8.7%
Tac + MMF/MPA + Steroids 31.8% 16.7% 37.5% 16.7% 41.7% 39.3% 39.1% 57.1% 43.5%
--- + OtherAntimet + Steroids 0.0% 0.0% 0.0% 5.6% 0.0% 3.6% 0.0% 0.0% 0.0%
CyA + OtherAntimet + Steroids 22.7% 8.3% 0.0% 11.1% 16.7% 7.1% 8.7% 0.0% 0.0%
Tac + OtherAntimet + Steroids 13.6% 20.8% 12.5% 16.7% 25.0% 21.4% 13.0% 14.3% 4.3%
--- + Siro/Evero + Steroids 0.0% 0.0% 0.0% 5.6% 0.0% 0.0% 0.0% 0.0% 0.0%
Tac + Siro/Evero + Steroids 9.1% 4.2% 12.5% 16.7% 0.0% 7.1% 4.3% 0.0% 0.0%
Other Regimen 4.5% 8.3% 0.0% 0.0% 0.0% 3.6% 4.3% 7.1% 8.7%


Source: OPTN/SRTR Data as of October 1, 2010.

Percentages are calculated based on the total number of patients with maintenance use at two years following transplantation. They sum to 100 percent for each column

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.