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Table 7.6h

Persistency of Discharge Regimen by Follow-up Period, 2004 to 2008

Recipients with Pancreas After Kidney (PAK) Transplants

  Year of Transplant
2004 2005 2006 2007 2008
Discharge Regimen (w/ or w/o Steroid Use) CyA+Aza At Discharge (N) - - - 1 -
At Discharge (%) - - - 100.0% -
6 Months PostTx (%) - - - 100.0% -
1 Year PostTx (%) - - - - -
2 Years PostTx (%) - - - - -
3 Years PostTx (%) - - - - -
CyA+MMF At Discharge (N) 18 13 7 6 3
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 88.9% 61.5% 85.7% 50.0% 100.0%
1 Year PostTx (%) 65.8% 46.2% 85.7% 50.0% 66.7%
2 Years PostTx (%) 59.8% 30.8% 85.7% 33.3% 66.7%
3 Years PostTx (%) 59.8% 30.8% 85.7% 33.3% -
CyA+Siro At Discharge (N) 7 5 6 1 3
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 71.4% 60.0% 83.3% 100.0% 100.0%
1 Year PostTx (%) 42.9% 20.0% 83.3% 100.0% 100.0%
2 Years PostTx (%) 14.3% 0.0% 66.7% 100.0% -
3 Years PostTx (%) 14.3% 0.0% 50.0% 100.0% -
Siro+MMF At Discharge (N) 9 5 2 1 1
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 75.0% 80.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 62.5% 60.0% 100.0% 100.0% 100.0%
2 Years PostTx (%) 62.5% 40.0% 100.0% 0.0% 100.0%
3 Years PostTx (%) 50.0% 40.0% 100.0% 0.0% -
Tac+Aza At Discharge (N) 1 3 - 1 1
At Discharge (%) 100.0% 100.0% - 100.0% 100.0%
6 Months PostTx (%) 100.0% 33.3% - 0.0% 100.0%
1 Year PostTx (%) 100.0% 33.3% - 0.0% 100.0%
2 Years PostTx (%) 0.0% 33.3% - 0.0% -
3 Years PostTx (%) 0.0% 33.3% - 0.0% -
Tac+MMF At Discharge (N) 239 217 190 190 161
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 79.5% 87.5% 89.9% 89.5% 85.7%
1 Year PostTx (%) 71.4% 80.5% 82.3% 83.1% 75.0%
2 Years PostTx (%) 62.6% 69.1% 75.5% 79.8% 68.7%
3 Years PostTx (%) 56.6% 62.8% 66.6% 70.0% -
Tac+Siro At Discharge (N) 33 21 21 - 2
At Discharge (%) 100.0% 100.0% 100.0% - 100.0%
6 Months PostTx (%) 75.2% 65.2% 76.2% - 100.0%
1 Year PostTx (%) 59.5% 65.2% 71.4% - 100.0%
2 Years PostTx (%) 56.2% 55.1% 66.7% - -
3 Years PostTx (%) 52.9% 50.1% 61.5% - -


Source: OPTN/SRTR Data as of October 1, 2010.

Regimen change is defined as being on different drug combination at follow-up comparing to discharge, or indication of conflicting regimen

(CyA vs. Tac; MMF/MPA vs. Aza; Siro vs. Evero) during follow-up period, or graft failure/death. Addition or deletion of steroids is not considered a regimen change.&

Rates are calculated for the most common discharge regimens.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.

See Technical Notes for further details.