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Table 8.6f

Immunosuppression Use for Maintenance by Regimen

One Year Following Transplantation, 1999 to 2008

Recipients with Kidney-Pancreas Transplants

  Transplant Year
1999 2000 2001 2002 2003 2004 2005 2006 2007 2008
Transplants 941 915 891 906 871 881 903 924 864 837
Functioning Graft at 1 Year PostTx 859 839 818 821 785 793 825 832 790 765
With Maintenance Use Recorded at 1 Year PostTx 839 809 798 797 779 788 815 814 756 745
CyA 0.2% 0.0% 0.1% 0.3% 0.0% 0.0% 0.2% 0.1% 0.0% 0.0%
Tac 0.5% 0.1% 1.5% 2.6% 1.7% 2.8% 1.8% 2.0% 1.3% 1.3%
--- + MMF/MPA 0.0% 0.1% 0.1% 0.1% 0.4% 1.0% 0.2% 0.1% 0.0% 0.1%
CyA + MMF/MPA 0.0% 0.0% 0.0% 0.3% 0.5% 0.1% 1.0% 0.4% 0.9% 0.7%
Tac + MMF/MPA 1.0% 2.7% 2.1% 4.9% 6.3% 9.8% 14.2% 20.1% 20.4% 17.9%
--- + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.0% 0.0%
CyA + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.0% 0.0%
Tac + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.1% 0.1% 0.0% 0.1%
Tac + MMF/MPA + OtherAntimet 0.0% 0.1% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.1%
--- + Siro/Evero 0.0% 0.1% 0.1% 0.4% 0.3% 0.0% 0.0% 0.0% 0.0% 0.3%
CyA + Siro/Evero 0.0% 0.2% 0.1% 0.0% 1.0% 2.2% 1.8% 2.3% 2.0% 2.1%
Tac + Siro/Evero 0.0% 3.0% 5.3% 7.3% 8.2% 6.0% 8.2% 3.3% 3.2% 2.6%
--- + MMF/MPA + Siro/Evero 0.0% 0.0% 0.1% 0.0% 1.5% 3.9% 1.5% 0.9% 0.7% 0.8%
CyA + MMF/MPA + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.3% 0.1% 0.0% 0.0% 0.0%
Tac + MMF/MPA + Siro/Evero 0.0% 0.1% 1.5% 0.9% 1.2% 1.0% 1.3% 3.3% 3.8% 1.9%
Tac + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.1% 0.0% 0.0% 0.1% 0.0% 0.0%
--- + Steroids 0.2% 0.4% 0.1% 1.3% 0.5% 0.5% 0.1% 0.2% 0.3% 0.3%
CyA + Steroids 1.9% 1.7% 1.1% 0.5% 0.4% 0.1% 0.1% 0.2% 0.1% 0.3%
Tac + Steroids 6.0% 4.0% 5.3% 4.4% 5.0% 2.7% 4.5% 3.7% 4.6% 5.0%
--- + MMF/MPA + Steroids 0.4% 0.4% 0.4% 0.5% 0.4% 0.8% 0.6% 0.2% 0.4% 0.9%
CyA + MMF/MPA + Steroids 18.6% 11.5% 8.3% 8.8% 6.8% 3.2% 2.3% 2.0% 2.6% 1.9%
Tac + MMF/MPA + Steroids 57.6% 56.0% 51.9% 50.7% 52.1% 55.1% 53.9% 53.1% 53.8% 59.2%
--- + OtherAntimet + Steroids 0.0% 0.0% 0.0% 0.0% 0.1% 0.1% 0.0% 0.0% 0.0% 0.0%
CyA + OtherAntimet + Steroids 0.1% 0.4% 0.1% 0.4% 0.0% 0.3% 0.0% 0.0% 0.3% 0.0%
Tac + OtherAntimet + Steroids 3.7% 1.7% 0.8% 1.5% 1.7% 1.0% 0.6% 1.2% 0.9% 1.6%
--- + Siro/Evero + Steroids 0.2% 0.5% 0.4% 0.3% 0.6% 0.3% 0.0% 0.1% 0.3% 0.0%
CyA + Siro/Evero + Steroids 0.5% 3.0% 2.5% 1.0% 1.5% 0.5% 0.6% 0.6% 0.8% 0.1%
Tac + Siro/Evero + Steroids 1.5% 6.7% 12.8% 10.0% 5.5% 5.2% 4.2% 3.2% 2.5% 1.6%
Other Regimen 7.6% 7.3% 5.4% 4.0% 4.1% 3.2% 2.3% 2.3% 1.1% 1.2%


Source: OPTN/SRTR Data as of October 1, 2010.

Percentages are calculated based on the total number of patients with maintenance use at one year following transplantation. They sum to 100 percent for each column.

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.