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Table 8.6h

Persistency of Discharge Regimen by Follow-up Period, 2004 to 2008

Recipients with Kidney-Pancreas Transplants

  Year of Transplant
2004 2005 2006 2007 2008
Discharge Regimen (w/ or w/o Steroid Use) CyA+Aza At Discharge (N) 1 - - - -
At Discharge (%) 100.0% - - - -
6 Months PostTx (%) 100.0% - - - -
1 Year PostTx (%) 100.0% - - - -
2 Years PostTx (%) 100.0% - - - -
3 Years PostTx (%) 100.0% - - - -
CyA+MMF At Discharge (N) 14 22 15 13 8
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 57.1% 90.9% 80.0% 100.0% 75.0%
1 Year PostTx (%) 50.0% 86.1% 53.3% 64.2% 75.0%
2 Years PostTx (%) 42.9% 75.7% 46.7% 51.3% -
3 Years PostTx (%) 42.9% 75.7% 40.0% 51.3% -
CyA+Siro At Discharge (N) 32 33 34 22 28
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 78.1% 68.9% 76.5% 86.4% 64.3%
1 Year PostTx (%) 50.0% 59.5% 67.6% 77.3% 57.1%
2 Years PostTx (%) 46.9% 56.2% 55.3% 59.1% 57.1%
3 Years PostTx (%) 43.8% 38.6% 40.6% 59.1% -
Siro+MMF At Discharge (N) 40 4 6 3 1
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 80.0% 100.0% 50.0% 66.7% 0.0%
1 Year PostTx (%) 65.0% 75.0% 33.3% 66.7% 0.0%
2 Years PostTx (%) 55.0% 75.0% 16.7% 66.7% 0.0%
3 Years PostTx (%) 49.8% 75.0% 16.7% 66.7% 0.0%
Tac+Aza At Discharge (N) 2 - 7 3 -
At Discharge (%) 100.0% - 100.0% 100.0% -
6 Months PostTx (%) 100.0% - 57.1% 33.3% -
1 Year PostTx (%) 100.0% - 28.6% 33.3% -
2 Years PostTx (%) 100.0% - 28.6% - -
3 Years PostTx (%) 100.0% - 28.6% - -
Tac+MMF At Discharge (N) 619 658 669 697 714
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 87.9% 91.3% 93.5% 92.9% 93.5%
1 Year PostTx (%) 81.9% 87.9% 89.9% 89.3% 89.4%
2 Years PostTx (%) 78.1% 84.5% 85.2% 84.4% 78.8%
3 Years PostTx (%) 75.7% 81.7% 82.6% 82.3% -
Tac+Siro At Discharge (N) 51 77 59 22 11
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 79.3% 84.4% 81.1% 90.5% 100.0%
1 Year PostTx (%) 71.0% 81.8% 79.4% 85.4% 100.0%
2 Years PostTx (%) 64.1% 75.2% 77.6% 53.6% 100.0%
3 Years PostTx (%) 57.2% 72.3% 66.5% 0.0% -


Source: OPTN/SRTR Data as of October 1, 2010.

Regimen change is defined as being on different drug combination at follow-up comparing to discharge, or indication of conflicting regimen

(CyA vs. Tac; MMF/MPA vs. Aza; Siro vs. Evero) during follow-up period, or graft failure/death. Addition or deletion of steroids is not considered a regimen change.&

Rates are calculated for the most common discharge regimens.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.

See Technical Notes for further details.