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Table 9.6f
Immunosuppression Use for Maintenance by Regimen
One Year Following Transplantation, 1999 to 2008
Recipients with Liver Transplants
Transplant Year
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
Transplants
4,755
5,001
5,195
5,332
5,673
6,171
6,444
6,651
6,494
6,319
Functioning Graft at 1 Year PostTx
3,658
3,900
4,095
4,307
4,579
5,013
5,124
5,447
5,397
5,254
With Maintenance Use Recorded at 1 Year PostTx
3,411
3,715
4,027
4,210
4,441
4,899
4,999
5,266
5,122
4,898
CyA
4.2%
3.1%
2.5%
2.5%
1.9%
1.9%
1.7%
1.9%
2.1%
1.9%
Tac
20.5%
23.6%
28.9%
31.3%
30.1%
28.3%
28.6%
26.6%
28.5%
28.3%
--- + MMF/MPA
0.1%
0.0%
0.1%
0.2%
0.4%
0.3%
0.3%
0.4%
0.4%
0.8%
CyA + MMF/MPA
1.6%
1.3%
1.4%
1.6%
1.9%
2.4%
2.9%
3.0%
2.9%
3.3%
Tac + MMF/MPA
5.5%
7.1%
7.3%
10.1%
13.7%
15.2%
18.1%
22.1%
25.1%
25.9%
--- + OtherAntimet
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
CyA + OtherAntimet
0.2%
0.1%
0.1%
0.0%
0.1%
0.2%
0.0%
0.0%
0.1%
0.0%
Tac + OtherAntimet
0.3%
0.5%
0.2%
0.5%
0.3%
0.6%
0.1%
0.2%
0.3%
0.5%
--- + MMF/MPA + OtherAntimet
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
CyA + MMF/MPA + OtherAntimet
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
Tac + MMF/MPA + OtherAntimet
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
--- + Siro/Evero
0.2%
0.8%
1.0%
1.7%
1.5%
2.0%
2.0%
1.9%
1.7%
1.6%
CyA + Siro/Evero
0.1%
0.9%
0.5%
0.3%
0.4%
0.3%
0.5%
0.3%
0.3%
0.3%
Tac + Siro/Evero
0.4%
2.4%
2.5%
2.3%
2.4%
2.9%
2.1%
1.2%
1.2%
1.2%
--- + MMF/MPA + Siro/Evero
0.0%
0.2%
0.4%
1.0%
1.1%
1.3%
2.4%
2.2%
1.8%
1.2%
CyA + MMF/MPA + Siro/Evero
0.1%
0.0%
0.0%
0.0%
0.0%
0.1%
0.1%
0.0%
0.0%
0.0%
Tac + MMF/MPA + Siro/Evero
0.0%
0.2%
0.1%
0.2%
0.3%
0.2%
0.2%
0.2%
0.3%
0.2%
--- + OtherAntimet + Siro/Evero
0.0%
0.0%
0.0%
0.0%
0.0%
0.1%
0.1%
0.0%
0.0%
0.0%
Tac + OtherAntimet + Siro/Evero
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
0.0%
--- + Steroids
1.8%
1.6%
0.6%
0.8%
0.5%
0.4%
0.3%
0.2%
1.0%
1.5%
CyA + Steroids
10.3%
5.8%
2.9%
2.3%
2.0%
1.7%
1.2%
1.2%
1.0%
0.9%
Tac + Steroids
30.5%
26.7%
22.8%
22.3%
20.9%
18.1%
15.7%
15.2%
12.6%
11.3%
--- + MMF/MPA + Steroids
0.4%
0.3%
0.3%
0.4%
0.4%
0.4%
0.4%
0.5%
0.4%
0.6%
CyA + MMF/MPA + Steroids
5.0%
4.0%
3.2%
2.0%
2.1%
2.0%
1.7%
1.5%
1.5%
1.5%
Tac + MMF/MPA + Steroids
10.4%
10.8%
13.2%
12.6%
14.1%
15.5%
16.8%
17.4%
15.1%
15.4%
--- + OtherAntimet + Steroids
0.0%
0.0%
0.0%
0.0%
0.1%
0.0%
0.0%
0.0%
0.0%
0.0%
CyA + OtherAntimet + Steroids
2.5%
1.7%
0.8%
0.3%
0.2%
0.3%
0.1%
0.0%
0.1%
0.0%
Tac + OtherAntimet + Steroids
1.4%
1.1%
1.4%
1.4%
1.0%
0.5%
0.3%
0.3%
0.3%
0.2%
--- + Siro/Evero + Steroids
0.1%
0.3%
1.0%
0.9%
0.8%
1.6%
1.3%
1.0%
0.9%
0.9%
CyA + Siro/Evero + Steroids
0.3%
0.3%
0.4%
0.3%
0.3%
0.1%
0.1%
0.0%
0.1%
0.2%
Tac + Siro/Evero + Steroids
0.6%
3.0%
2.3%
2.1%
1.5%
1.5%
1.2%
0.9%
0.8%
0.9%
Other Regimen
3.6%
4.3%
5.8%
2.7%
2.1%
1.8%
1.6%
1.7%
1.5%
1.3%
Source: OPTN/SRTR Data as of October 1, 2010.
Percentages are calculated based on the total number of patients with maintenance use at one year following transplantation. They sum to 100 percent for each column.
---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.
MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.
"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.