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Table 9.6h

Persistency of Discharge Regimen by Follow-up Period, 2004 to 2008

Recipients with Liver Transplants

  Year of Transplant
2004 2005 2006 2007 2008
Discharge Regimen (w/ or w/o Steroid Use) CyA+Aza At Discharge (N) 58 14 5 7 7
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 44.8% 35.7% 60.0% 57.1% 42.9%
1 Year PostTx (%) 27.6% 7.1% 40.0% 14.3% 0.0%
2 Years PostTx (%) 17.2% 7.1% 0.0% 14.3% 0.0%
3 Years PostTx (%) 17.2% 7.1% 0.0% - 0.0%
CyA+MMF At Discharge (N) 232 215 241 250 260
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 66.0% 73.1% 76.8% 78.8% 80.7%
1 Year PostTx (%) 49.9% 61.6% 59.0% 63.2% 62.9%
2 Years PostTx (%) 41.4% 53.8% 47.5% 52.3% 51.2%
3 Years PostTx (%) 35.8% 49.6% 41.2% 49.6% -
CyA+Siro At Discharge (N) 27 34 42 34 29
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 66.7% 58.8% 57.1% 50.0% 58.6%
1 Year PostTx (%) 27.5% 52.8% 35.7% 44.1% 44.0%
2 Years PostTx (%) 15.7% 36.3% 21.4% 34.3% 44.0%
3 Years PostTx (%) 3.9% 29.0% 8.6% 29.4% -
Siro+MMF At Discharge (N) 46 50 48 37 39
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 60.1% 77.6% 64.6% 78.4% 76.5%
1 Year PostTx (%) 35.6% 67.1% 50.8% 64.2% 58.3%
2 Years PostTx (%) 28.0% 50.3% 38.7% 51.9% 49.9%
3 Years PostTx (%) 25.4% 39.8% 38.7% 45.4% -
Tac+Aza At Discharge (N) 52 23 14 25 11
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 51.9% 69.6% 53.8% 64.0% 72.7%
1 Year PostTx (%) 36.5% 41.7% 53.8% 55.4% 58.2%
2 Years PostTx (%) 30.8% 41.7% 53.8% 46.2% 29.1%
3 Years PostTx (%) 23.1% 32.5% 44.9% 46.2% -
Tac+MMF At Discharge (N) 2,667 3,100 3,704 3,850 4,043
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 72.2% 79.4% 82.6% 85.4% 86.3%
1 Year PostTx (%) 57.8% 67.8% 71.8% 75.0% 75.6%
2 Years PostTx (%) 48.3% 59.5% 63.3% 65.0% 64.6%
3 Years PostTx (%) 43.3% 54.7% 57.8% 59.1% -
Tac+Siro At Discharge (N) 102 61 72 30 23
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 62.7% 71.2% 70.8% 63.3% 65.2%
1 Year PostTx (%) 41.7% 56.0% 52.2% 48.4% 50.7%
2 Years PostTx (%) 40.6% 44.1% 43.5% 39.1% -
3 Years PostTx (%) 32.3% 40.6% 34.7% 39.1% -


Source: OPTN/SRTR Data as of October 1, 2010.

Regimen change is defined as being on different drug combination at follow-up comparing to discharge, or indication of conflicting regimen

(CyA vs. Tac; MMF/MPA vs. Aza; Siro vs. Evero) during follow-up period, or graft failure/death. Addition or deletion of steroids is not considered a regimen change.&

Rates are calculated for the most common discharge regimens.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.

See Technical Notes for further details.