DOD
OPTN/SRTR 2015 Annual Data Report: Deceased Organ Donation
Abstract
SRTR uses data collected by OPTN to calculate metrics such as donation/conversion rate, organ yield, and rate of organs recovered for transplant but not transplanted. In 2015, 1,072,828 death and imminent death referrals were made to Organ Procurement Organizations, of which 21,559 met the definition of eligible (9793) or imminent (11,766) deaths per OPTN policy. The number of deceased donors was 9080, and this number has been increasing since 2010. The number of organs authorized for recovery increased slightly to 65,086 in 2015, and the number recovered increased slightly to 25,762. In 2015, 4370 organs were discarded, including 3157 kidneys, 311 pancreata, 703 livers, 30 hearts, and 214 lungs. These numbers suggest a need to reduce the number of organs discarded.
Introduction
This chapter reports data collected by the Organ Procurement and Transplantation Network (OPTN) to describe metrics such as donation/conversion rate, organ yield, and rate of organs recovered for transplant but not transplanted.
Definitions of Terms Related to Deceased Organ Donation
- Referrals: All deaths and imminent deaths that were reported to the organ procurement organization.
- Eligible death: As per OPTN policy, death of a person aged 70 years or younger who is legally declared brain dead according to hospital policy and does not exhibit any of the following indications: tuberculosis, human immunodeficiency virus (HIV) infection with specified conditions, Creutzfeldt-Jacob Disease, herpetic septicemia, rabies, reactive hepatitis B surface antigen, any retrovirus infection, active malignant neoplasms (except primary central nervous system tumors and skin cancers), Hodgkin disease, multiple myeloma, leukemia, miscellaneous carcinomas, aplastic anemia, agranulocytosis, fungal and viral encephalitis, gangrene of bowel, extreme immaturity, or positive serological or viral culture findings for HIV.
- Donor: A person from whom at least one organ was procured for the purpose of transplant, regardless of whether the organ was transplanted.
- Eligible donor: A donor whose death met the definition of eligible death.
- Organs authorized for recovery: Consent requested and given for recovery of specific organs from a donor.
- Donation/conversion rate: Number of eligible donors per 100 eligible deaths.
- Organ-specific donation/conversion rate: Number of donors of each organ type who met eligibility criteria per 100 eligible deaths.
- Organs recovered per donor (ORPD): Total number of organs recovered divided by the number of donors, not limited to eligible deaths.
- Organs transplanted per donor (OTPD): Total number of organs transplanted divided by the number of donors, not limited to eligible deaths.
- Organ yield metric: Ratio of observed to expected numbers of organs transplanted; expected numbers based on national experience with similar donors.
- Rate of organs recovered for transplant but not transplanted: Calculated by dividing the number of organs recovered for the purpose of transplant but not transplanted by the number of organs recovered for the purpose of transplant.
- Expanded criteria donors (ECD): Donors aged 60 years or older, or aged 50-59 years with two of the following: hypertension, terminal creatinine greater than 1.5 mg/dL, or death from cerebrovascular accident. This definition was developed by OPTN for kidney donors but has been used to classify donors in general.
Eligible Deaths
In 2015, 1,072,828 death and imminent death referrals were made to organ procurement organizations, of which 21,559 met the definition of eligible (9793) or imminent (11,766) deaths per OPTN policy. The number of deceased donors was 9080, and this number has been increasing since 2010. The number of deceased donor transplants increased to 24,980. This is in contrast to the 5989 living donor transplants in 2015 (Figure DOD 2). The number of organs authorized for recovery increased slightly to 65,086 in 2015, and the number recovered and transplanted increased to 25,762 organs (Figure DOD 3).
Donation or Conversion Rate
The OPTN requires that organ procurement organizations (OPOs) report all eligible deaths. However, any performance metric based solely on eligible deaths uses only a subset of potential donors, since successful donations can come from donors not meeting the eligible death definition, e.g., donations after cardiac death or donors aged older than 70 years. Recognizing this limitation, the SRTR's current donation/conversion rate is a measure of how often an eligible death becomes a donor. In 2015, the donation/conversation rate was 72.2 eligible donors per 100 eligible deaths, a slight decrease from 73.4 in 2014. Unadjusted donation or conversion rates varied by donation service area (DSA), ranging from 59.3 to 89.3 (Figure DOD 4).
The conversation rate varied by organ. The highest rate was 66.3 eligible donors per 100 eligible deaths for kidneys, for 6489 kidney donors from 9793 eligible deaths. The lowest conversion rate was 12.4 for pancreas donors, with 1215 donors (Figure DOD 5).
Organs Recovered per Donor
In 2015, this number was 3.51, slightly higher than 3.50 in 2014 and lower than 3.55 in 2013 (Figure DOD 6). The ORPD for each organ has been stable compared to 2014 (Figure DOD 6, Figure DOD 7). In 2015, the ORPD varied substantially by DSA, ranging from 2.89 to 4.12 (Figure DOD 8, Figure DOD 15). The ORPD is an unadjusted number and thus represents a mix of donor types, including standard criteria donors (SCDs), ECDs, and donation after circulatory death (DCD). The ORPD for kidneys varied from 1.57 to 1.96; for pancreata, from 0.02 to 0.35; for livers, from 0.58 to 0.95; for intestines, from 0.0 to 0.09; for hearts, from 0.07 to 0.44; and for lungs, from 0.12 to 0.69 (Figure DOD 9, Figure DOD 10, Figure DOD 11, Figure DOD 12, Figure DOD 13, Figure DOD 14).
Organs Transplanted per Donor and Organ Yield
The mean number of OTPD was 3.03 in 2015, similar to 2014 and slightly lower than 3.08 in 2013 (Figure DOD 16). The OTPD for each organ was stable compared to 2014 (Figure DOD 16, Figure DOD 17). In a 2015 unadjusted analysis, not accounting for the mix of SCD, ECD, and DCD donor types, the OTPD varied substantially by DSA, ranging from 2.46 to 3.71 (Figure DOD 18, Figure DOD 25). The OTPD for kidneys varied from 1.20 to 1.76; for pancreata, from 0.02 to 0.24; for livers, from 0.56 to 0.93; for intestines, from 0.0 to 0.07; for hearts, from 0.05 to 0.44; and for lungs, from 0.12 to 0.63 (Figure DOD 19, Figure DOD 20, Figure DOD 21, Figure DOD 22, Figure DOD 23, Figure DOD 24).
The OTPD from donation after brain death (DBD) was 3.25 in 2015, slightly higher than 3.22 in 2014, and slightly lower than 3.29 in 2013. The OTPD from DCD donors was 1.93 in 2015, slightly lower than 1.97 in 2014 and slightly higher than 1.88 in 2013 (Figure DOD 26). In 2015, of the 9080 donors, 16% nationally were DCD donors, slightly higher than 15% in 2014.
The average numbers of kidneys transplanted per donor were 1.44 for DBD (10,921 kidneys) and 1.56 for DCD (2332 kidneys) donors in 2015 (Figure DOD 27). The average number of kidneys transplanted varied by kidney donor profile index (KDPI), and was 1.94, 1.83, 1.55, and 0.60 for KDPI below 0.20, 0.21-0.34, 0.35-0.85, and above 0.85, respectively (Figure DOD 33). Comparing the OTPD from DBD versus DCD donors shows that, apart from kidney donors, the OTPD was higher from DBD than from DCD donors (Figure DOD 28, Figure DOD 29, Figure DOD 30, Figure DOD 31, Figure DOD 32). The OTPD for kidneys has been higher from DCD than from DBD donors since 2006 (Figure DOD 27). The number of DCD liver donors continued to increase from 184 in 2004 to 405 in 2015.
The yield metric shown compares the number of organs transplanted (observed) in 2014-2015 with the number of organs that would be expected to be transplanted in 2014-2015 based on the national experience with similar donors (expected). A ratio, expressed as observed/expected organs transplanted, of less than 1 indicates that fewer organs were transplanted than would be expected based on the national models for that organ. A ratio of greater than 1 indicates that more organs were transplanted than would be expected. The mean observed/expected ratio for all organs varied from 0.89 to 1.14. The mean observed/expected ratio for kidneys varied from 0.85 to 1.18; for pancreata, from 0.38 to 2.73; for livers, from 0.84 to 1.20; for intestines, from 0.0 to 4.10; for hearts, from 0.66 to 1.32; and for lungs, from 0.45 to 1.41 (Figure DOD 34, Figure DOD 35, Figure DOD 36, Figure DOD 37, Figure DOD 38, Figure DOD 39).
Rate of Organs Recovered for Transplant but Not Transplanted
The number of organs recovered for transplant but not transplanted is calculated by subtracting the number of organs transplanted from the number of organs recovered for the purpose of transplant. The rate of organs not transplanted is then calculated by dividing the number of organs not transplanted by the number of organs recovered for the purpose of transplant. The rate in 2015 for all organs combined was 0.14 per recovered organ, slightly higher than 0.13 in 2014 and in 2013 (Figure DOD 40). In 2015, 4370 organs were discarded, including 3157 kidneys, 311 pancreata, 703 livers, 17 intestines, 30 hearts, and 214 lungs (Figure DOD 40).
Use of DCD organs for kidney and liver transplant also varied (Figure DOD 41). The proportion of DCD donor organs among deceased donor kidney transplant recipients varied across DSAs from 0.01 to 0.39. At twelve DSAs, less than 10% of kidneys were from DCD donors. Similarly, the proportion of DCD donor organs among deceased donor liver transplant recipients varied across DSAs from 0 to 0.23 (Figure DOD 42). Four DSAs had no livers from DCD donors. The percentage of donors with KDPI greater than 0.85 also varied across the DSAs, ranging from 0 to 14.6 (Figure DOD 43). The DSAs with higher percentages of donors with KPDI greater than 0.85 were not always the same DSAs that had more DCD kidneys.
In addition to high-KDPI kidneys, other higher risk kidneys are those with increased risk of infectious disease transmission. The Centers for Disease Control and Prevention (CDC) stipulates standard criteria for donors thought to have a higher risk for infectious disease transmission. Of 2016 CDC high-risk donors in 2015, two kidneys were transplanted from 1291, one kidney from 189, and a liver from 1582.
These metrics show variation across DSAs in use of DCD donors; the highest number of discards was for kidney (3157). This suggests that sharing best practices between OPOs and their transplant centers could lead to gains in efficiency and organ retrieval, especially for marginal organs such as DCD livers and kidneys and kidneys with KDPI greater than 0.85.
The disposition of donors is described in Figure DOD 44, Figure DOD 45, Figure DOD 46, Figure DOD 47, Figure DOD 48, Figure DOD 49, Figure DOD 50, and Figure DOD 51.
Figure List
Summary
Figure DOD 1. Relationship between deaths, donations, and transplants
Figure DOD 2. Overall counts of eligible deaths, donors, and transplants, 2004-2015
Figure DOD 3. Overall counts of authorized and recovered organs, 2004-2015
Donation rates
Figure DOD 4. Overall donations per 100 eligible deaths by DSA, 2015
Figure DOD 5. Overall and organ-specific donations per 100 eligible deaths, 2015
Organs recovered per donor
Figure DOD 6. Organs recovered per donor, all organs and kidney
Figure DOD 7. Organs recovered per donor, pancreas, liver, intestine, heart, and lung
Figure DOD 8. DSA distribution of all organs recovered per donor, 2015
Figure DOD 9. DSA distribution of kidneys recovered per donor, 2015
Figure DOD 10. DSA distribution of pancreata recovered per donor, 2015
Figure DOD 11. DSA distribution of livers recovered per donor, 2015
Figure DOD 12. DSA distribution of intestines recovered per donor, 2015
Figure DOD 13. DSA distribution of hearts recovered per donor, 2015
Figure DOD 14. DSA distribution of lungs recovered per donor, 2015
Figure DOD 15. Organs recovered per donor by DSA, 2015
Organs transplanted per donor
Figure DOD 16. Organs transplanted per donor, all organs and kidney
Figure DOD 17. Organs transplanted per donor, pancreas, liver, intestine, heart, and lung
Figure DOD 18. DSA distribution of all organs transplanted per donor, 2015
Figure DOD 19. DSA distribution of kidneys transplanted per donor, 2015
Figure DOD 20. DSA distribution of pancreata transplanted per donor, 2015
Figure DOD 21. DSA distrbution of livers transplanted per donor, 2015
Figure DOD 22. DSA distribution of intestines transplanted per donor, 2015
Figure DOD 23. DSA distrbution of hearts transplanted per donor, 2015
Figure DOD 24. DSA distribution of lungs transplanted per donor, 2015
Figure DOD 25. Organs transplanted per donor, by DSA, 2015
Figure DOD 26. Organs transplanted per donor, by DBD and DCD status
Figure DOD 27. Kidneys transplanted per donor, by DBD and DCD status
Figure DOD 28. Pancreata transplanted per donor, by DBD and DCD status
Figure DOD 29. Livers transplanted per donor, by DBD and DCD status
Figure DOD 30. Intestines transplanted per donor, by DBD and DCD status
Figure DOD 31. Hearts transplanted per donor, by DBD and DCD status
Figure DOD 32. Lungs transplanted per donor, by DBD and DCD status
Figure DOD 33. Kidneys transplanted per donor, by KDPI
Yield
Figure DOD 34. Observed-to-expected yield per kidney, 2014-2015
Figure DOD 35. Observed-to-expected yield per pancreas, 2014-2015
Figure DOD 36. Observed-to-expected yield per liver, 2014-2015
Figure DOD 37. Observed-to-expected yield per intestine, 2014-2015
Figure DOD 38. Observed-to-expected yield per heart, 2014-2015
Figure DOD 39. Observed-to-expected yield per lung, 2014-2015
Organ recovered for transplant and not transplanted
Figure DOD 40. Organs recovered for transplant and not transplanted
Organ quality
Figure DOD 41. Variation in proportions of DCD kidney donors among deceased donor transplant recipients, by DSA, 2015
Figure DOD 42. Variation in proportions of DCD liver donors among deceased donor transplant recipients, by DSA, 2015
Figure DOD 43. Variation in percentage of donors with KDPI greater than 85% among deceased donor kidney transplant recipients, by DSA, 2015
Organ use charts
Figure DOD 44. Organ use chart for reported left kidneys
Figure DOD 45. Organ use chart for reported right kidneys
Figure DOD 46. Organ use chart for reported en bloc kidneys
Figure DOD 47. Organ use chart for pancreas
Figure DOD 48. Organ use chart for liver
Figure DOD 49. Organ use chart for intestine
Figure DOD 50. Organ use chart for heart
Figure DOD 51. Organ use chart for lung
Table List
Donor characteristics
Table DOD 1. Characteristics of donors, 2005-2015
Table DOD 1 Characteristics of donors, 2005-2015 The donor characteristics of age, sex, race/ethnicity and DCD status in 2005 and 2015.
Characteristic | 2005, N | 2005, Percent | 2015, N | 2015, Percent |
Age: <18 years | 3473 | 13.6% |
3348 | 11.1% | Age: 18-34 years
| 8302 | 32.4% | 10,879 |
36.2% | Age: 35-49 years | 6624 |
25.9% | 7726 | 25.7% |
Age: 50-64 years | 5528 | 21.6% |
6694 | 22.3% | Age: ≥65 years
| 1676 | 6.5% | 1413 |
4.7% | Sex: Female | 10,109 |
39.5% | 11,458 | 38.1% |
Sex: Male | 15,494 | 60.5% |
18,602 | 61.9% | Race/ethnicity: White
| 17,488 | 68.3% | 19,491 |
64.8% | Race/ethnicity: Black | 3766 |
14.7% | 5243 | 17.4% |
Race/ethnicity: Hispanic | 3590 | 14.0% |
4288 | 14.3% |
Race/ethnicity: Other/unkown | 759 | 3.0% |
1038 | 3.5% | DCD status: DBD
| 24,353 | 95.1% | 26,787 |
89.1% | DCD status: DCD | 1250 |
4.9% | 3273 | 10.9% |
|